Special anesthesia for intrathoracic procedures are of great importance and studies concerning the best anesthetic protocols as well as clinical application of one-lung ventilation (OLV) in dogs are scarce. The aim of the study is to evaluate OLV in dogs, as well as to define the best protocol for hemodynamic variables and tissue perfusion between two isoflurane concentrations and propofol continuous rate infusion. Seven beagle dogs will be included in the study, of both genders, with previously determined individual minimum alveolar concentration (MAC) for isoflurane. Each dog will undergo three groups: 1.0 MAC isoflurane (GI1.0), 1.5 MAC isoflurane (GI1.5) or continuous infusion of propofol at 0.4 to 0.6 mg.kg-1.minute-1 (GP), and all groups will be given IV boluses of atracurium at 0.2 mg.kg-1. Patients will be intubated with a left double-lumen endotracheal tube and positioned in right lateral recumbency, initially undergoing two-lung ventilation (TLV) for 30 minutes. The left lung will then be ventilated with intermittent positive pressure of 10 cmH2O and positive end-expiratory pressure of 5 cmH2O while the right lung will be receiving continuous positive airway pressure (CPAP) for one hour. Finally, TLV will be restored for another 30 minutes, after which anesthesia will be discontinued. At 30, 50, 70, 90 and 120 minutes after the first TLV, variables will be recorded: heart rate (HR), systolic (SAP), mean (MAP) and diastolic (DAP) arterial pressures, cardiac (CI) and systolic (SI) indexes, left ventricle work index (LVWI), total peripheral resistance index (TPRI) and pulmonary vascular resistance index (PVRI), arterial and mixed-venous blood gas analysis, arterial blood lactate, alveolar-arterial oxygen gradient (P(A - a)O2), shunt fraction (Qs/Qt), oxygen delivery (DO2) and consumption (VO2), oxygen extraction rate (O2ER) and oxygenation index (OI).
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