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Hemodynamic effects of one-lung ventilation in dogs anesthetized by either isoflurane or continuous infusion of propofol.

Grant number: 13/05062-4
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2013
Effective date (End): August 09, 2015
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal Investigator:Valéria Nobre Leal de Souza Oliva
Grantee:Beatriz Perez Floriano
Host Institution: Faculdade de Medicina Veterinária (FMVA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


Special anesthesia for intrathoracic procedures are of great importance and studies concerning the best anesthetic protocols as well as clinical application of one-lung ventilation (OLV) in dogs are scarce. The aim of the study is to evaluate OLV in dogs, as well as to define the best protocol for hemodynamic variables and tissue perfusion between two isoflurane concentrations and propofol continuous rate infusion. Seven beagle dogs will be included in the study, of both genders, with previously determined individual minimum alveolar concentration (MAC) for isoflurane. Each dog will undergo three groups: 1.0 MAC isoflurane (GI1.0), 1.5 MAC isoflurane (GI1.5) or continuous infusion of propofol at 0.4 to 0.6 (GP), and all groups will be given IV boluses of atracurium at 0.2 Patients will be intubated with a left double-lumen endotracheal tube and positioned in right lateral recumbency, initially undergoing two-lung ventilation (TLV) for 30 minutes. The left lung will then be ventilated with intermittent positive pressure of 10 cmH2O and positive end-expiratory pressure of 5 cmH2O while the right lung will be receiving continuous positive airway pressure (CPAP) for one hour. Finally, TLV will be restored for another 30 minutes, after which anesthesia will be discontinued. At 30, 50, 70, 90 and 120 minutes after the first TLV, variables will be recorded: heart rate (HR), systolic (SAP), mean (MAP) and diastolic (DAP) arterial pressures, cardiac (CI) and systolic (SI) indexes, left ventricle work index (LVWI), total peripheral resistance index (TPRI) and pulmonary vascular resistance index (PVRI), arterial and mixed-venous blood gas analysis, arterial blood lactate, alveolar-arterial oxygen gradient (P(A - a)O2), shunt fraction (Qs/Qt), oxygen delivery (DO2) and consumption (VO2), oxygen extraction rate (O2ER) and oxygenation index (OI).

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FLORIANO, BEATRIZ P.; TREIN, THOMAS A.; WAGATSUMA, JULIANA T.; FERREIRA, JOANA Z.; PINHO, RENATA H.; SANTOS, PAULO S. P.; OLIVA, VALERIA N. L. S.. Pulmonary hemodynamics and alveolar oxygenation in healthy dogs anesthetized with propofol or isoflurane during one-lung ventilation in a closed-thoracic experimental model. AMERICAN JOURNAL OF VETERINARY RESEARCH, v. 78, n. 10, p. 1117-1125, . (13/05062-4)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FLORIANO, Beatriz Perez. Hemodynamic effects of one-lung ventilation in dogs anesthetized by isoflurane or continuous infusion of propofol. 2016. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária. Araçatuba Araçatuba.

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