| Full text | |
| Author(s): |
Morais, Aline T. do B.
[1]
;
Ferreira, Irlon M.
[2]
;
Jimenez, David E. Q.
[1]
;
Porto, Andre L. M.
[1]
Total Authors: 4
|
| Affiliation: | [1] Univ Sao Paulo, Inst Quim Sao Carlos, Lab Quim Organ & Biocatalise, Ave Joao Dagnone, 1100, Ed Quim Ambiental, BR-13563120 Sao Carlos, SP - Brazil
[2] Univ Fed Amapa, Colegiado Quim, Grp Biocatalise & Biotransformacao Quim Organ, Rod Juscelino Kubitschek, Km 2, BR-68902280 Macapa, AP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY; v. 16, p. 314-319, OCT 2018. |
| Web of Science Citations: | 1 |
| Abstract | |
Chiral chlorohydrins are used as intermediates in the synthesis of various compounds with biological activities. This paper reports the synthesis of alpha-chloroketones 2a-c with oxone (R) and NH4Cl at reflux via 30 min of exposure to microwave irradiation and conventional heating, in situ, followed by reduction with whole cells of marine-derived fungi (Penicillium citrinum CBMAI 1186, Mucor racemosus CBMAI 847, Aspergillus sydowii CBMAI 935, Penicillium raistrickii CBMAI 931, and Penicillium oxalicum CBMAI 1185), yielding the respective chlorohydrins 3a-c with good conversion (32-97%) and enantioselectivities (60-94%). This is the first study involving the synthesis of alpha-chlorophenones in situ followed by biocatalytic reduction from whole cells of marine-derived fungi to obtain enantio-enriched chlorohydrins 3a-c. (AU) | |
| FAPESP's process: | 13/50201-2 - Biodegrading of the organophosphate pesticide profenofós by marine fungi |
| Grantee: | Andre Luiz Meleiro Porto |
| Support Opportunities: | Regular Research Grants - Publications - Books published abroad |