| Full text | |
| Author(s): |
Braga-Sa, Michelle B. P.
[1]
;
Barros, Paulo S. M.
[1]
;
Jorge, Juliana S.
[1]
;
Dongo, Pamela
[1]
;
Finkensieper, Paula
[2]
;
Bolzan, Aline A.
[1]
;
Watanabe, Sung S.
[3]
;
Safatle, Angelica M. V.
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Cirurgia, Lab Invest Oftalmol Comparada, Ave Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med, Lab Anestesiol, Av Dr Arnaldo 455, BR-01246903 Sao Paulo, SP - Brazil
[3] Univ Fed Sao Paulo Unifesp, Fac Med, Rua Sena Madureira 1500, BR-04021001 Sao Paulo, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Pesquisa Veterinária Brasileira; v. 38, n. 10, p. 1966-1971, OCT 2018. |
| Web of Science Citations: | 0 |
| Abstract | |
ABSTRACT: Diabetes mellitus is one of the most common endocrine disorders characterized by relative or absolute lack of insulin; this can lead to several ocular manifestations, among them diabetic retinopathy and cataracts. Diabetic retinopathy (DR) is a microangiopathy that involves retinal precapillary arterioles, postcapillary venules, and large vessels, causing them to be functionally and anatomically incompetent. Hyperglycemia seems to be the most probable cause of damage to the retina due to interference in cellular metabolism and transduction processes. The aim of this study was to evaluate retinal thickness in eight diabetic dogs, four females and four males of different breeds and ages ranging from 6 to 15 years, by optical coherence tomography (OCT) and to compare them with non-diabetic dogs. Assessment provided by OCT in diabetic dogs showed retinal layers thinning and loss of stratification when compared to non-diabetic dogs (198μm versus 219μm respectively), with statistical significance (p=0.008). OCT images may suggest that diabetes mellitus causes retinal neuropathy in dogs, as also seen in diabetic humans. (AU) | |
| FAPESP's process: | 11/24039-8 - Use of optical coherence tomography in retinal diseases in dogs |
| Grantee: | Angélica de Mendonça Vaz Safatle |
| Support Opportunities: | Regular Research Grants |