Benefits of resistance training on body composition and glucose clearance are inhibited by long-term low carbohydrate diet in rats

Author(s)

Stotzer, Uliana Sbeguen ^[1] ; Deriggi Pisani, Graziele Fernanda ^[1] ; Rigo Canevazzi, Gustavo Henrique ^[1] ; Shiguemoto, Gilberto Eiji ^[1] ; de Oliveira Duarte, Ana Claudia Garcia ^[2] ; de Andrade Perez, Sergio Eduardo ^[1] ; Selistre-de-Araujo, Heloisa Sobreiro ^[1]

Affiliation

^[1] Univ Fed Sao Carlos, Dept Physiol Sci, Sao Carlos, SP - Brazil

^[2] Univ Fed Sao Carlos, Dept Phys Educ & Human Motr, Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: PLoS One; v. 13, n. 12 DEC 7 2018.
• Web of Science Citations: 0

Abstract

Background/Objectives Regular exercise training is effective to altering many markers of metabolic syndrome and its effects are strongly influenced by the type of consumed diet. Nowadays, resistance training (RT) has been frequently associated with low-carbohydrate high-fat diet (LCD). After long term these diets causes body weight (BW) regain with deleterious effects on body composition and metabolic risk factors. The effects of RT associated with long-term LCD on these parameters remain unexplored. We aimed to investigate the effects of RT when associated with long-term LCD on BW, feed efficiency, body composition, glucose homeostasis, liver parameters and serum biochemical parameters during BW regain period in rats. Subjects/Methods Male Sprague-Dawley rats were fed with LCD (LC groups) or standard diet (STD) (ST groups). After 10 weeks-diet animals were separated into sedentary (Sed-LC and Sed-ST) and resistance-trained (RT-LC and RT-ST) groups (N = 8/group). RT groups performed an 11-week climbing program on a ladder with progressive load. Dual x-ray absorptiometry, glucose tolerance tests and insulin tolerance tests were performed at weeks 10 and 20. Liver and serum were collected at week 21. Results RT reduced feed efficiency, BW gain, liver fat and total and LDL cholesterol, and improved body composition and glucose clearance in animals fed on STD. In those fed with LCD, RT reduced caloric intake, BW regain, liver fat and serum triglycerides levels. However, improvement in body composition was inhibited and bone mineral density and glucose clearance was further impaired in this association. Conclusions The LCD nullifies the beneficial effects of RT on body composition, glucose homeostasis and impairs some health parameters. Our results do not support the association of RT with LCD in a long term period. (AU)

• FAPESP's process: 13/00798-2 - The extracellular matrix in aging, exercise and in the tumor microenvironment
• Grantee: Heloisa Sobreiro Selistre de Araújo
• Support Opportunities: Research Projects - Thematic Grants