The A-Z of Zika drug discovery

Author(s):Show less -

Mottin, Melina ^[1] ; Borba, Joyce V. V. B. ^[1] ; Braga, Rodolpho C. ^[1] ; Torres, Pedro H. M. ^{[2, 3]} ; Martini, Matheus C. ^[4] ; Proenca-Modena, Jose Luiz ^[4] ; Judice, Carla C. ^[5] ; Costa, Fabio T. M. ^[5] ; Ekins, Sean ^[6] ; Perryman, Alexander L. ^[7] ; Andrade, Carolina Horta ^{[5, 1]}

Affiliation

^[1] Univ Fed Goias, Fac Farm, LabMol Lab Mol Modeling & Drug Design, BR-74605170 Goiania, Go - Brazil

^[2] Univ Cambridge, Dept Biochem, 80 Tennis Court Rd, Cambridge CB2 1GA - England

^[3] Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, BR-21040900 Rio De Janeiro, RJ - Brazil

^[4] Univ Estadual Campinas, Lab Emerging Viruses LEVE, Dept Genet Evolut Microbiol & Immunol, Inst Biol, BR-13083864 Campinas, SP - Brazil

^[5] Univ Estadual Campinas, Lab Trop Dis Prof Dr Luiz Jacintho da Silva, Dept Genet Evolut Microbiol & Immunol, Inst Biol, BR-13083864 Campinas, SP - Brazil

^[6] Collaborat Pharmaceut Inc, 840 Main Campus Dr, Lab 3510, Raleigh, NC 27606 - USA

^[7] Rutgers State Univ, New Jersey Med Sch, Dept Pharmacol Physiol & Neurosci, Newark, NJ 07103 - USA

• Document type: Review article
• Source: DRUG DISCOVERY TODAY; v. 23, n. 11, p. 1833-1847, NOV 2018.
• Web of Science Citations: 10

Abstract

Despite the recent outbreak of Zika virus (ZIKV), there are still no approved treatments, and early-stage compounds are probably many years away from approval. A comprehensive A-Z review of the recent advances in ZIKV drug discovery efforts is presented, highlighting drug repositioning and computationally guided compounds, including discovered viral and host cell inhibitors. Promising ZIKV molecular targets are also described and discussed, as well as targets belonging to the host cell, as new opportunities for ZIKV drug discovery. All this knowledge is not only crucial to advancing the fight against the Zika virus and other flaviviruses but also helps us prepare for the next emerging virus outbreak to which we will have to respond. (AU)

• FAPESP's process: 12/16525-2 - Plasmodium vivax: pathogenesis and infectivity
• Grantee: Fabio Trindade Maranhão Costa
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 16/00194-8 - Pathogenesis and neurovirulence of emerging viruses in Brazil
• Grantee: José Luiz Proença Módena
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 17/02353-9 - Bioinformatics, Chemiogenomics and Chemioinformatics applied to the Discovery of New Drugs and Biotechnological Products
• Grantee: Fabio Trindade Maranhão Costa
• Support Opportunities: Research Grants - Visiting Researcher Grant - Brazil
• FAPESP's process: 16/13805-5 - Mechanism of action of Lipoxin in the Protection Against Experimental Cerebral Malaria
• Grantee: Fabio Trindade Maranhão Costa
• Support Opportunities: Regular Research Grants