Infections Caused by Fusarium Species in Pediatric Cancer Patients and Review of Published Literature

Author(s):Show less -

Arnoni, Mariana Volpe ^[1] ; Paula, Claudete Rodrigues ^[2] ; Auler, Marcos Ereno ^[3] ; Naozuka Simoes, Cirilo Cesar ^[1] ; Nakano, Shirley ^[1] ; Szeszs, Maria Walderez ^[4] ; Carvalho Melhem, Marcia de Souza ^[4] ; Richini Pereira, Virginia Bodelao ^[5] ; Garces, Hans Garcia ^[6] ; Bagagli, Eduardo ^[6] ; Silva, Eriques Goncalves ^[2] ; de Macedo, Melissa Ferreira ^[1] ; Ruiz, Luciana da Silva ^{[5, 7]}

Affiliation

^[1] Hosp Infantil Darcy Vargas, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Fac Odontol, Sao Paulo, SP - Brazil

^[3] Univ Estadual Ctr Oeste Parana UNICENTRO, Dept Farm, Guarapuava, PR - Brazil

^[4] IAL, Seccao Micol, Sao Paulo, SP - Brazil

^[5] IAL, Nucleo Ciencias Biomed, CLR 2, Bauru, SP - Brazil

^[6] Univ Estadual Paulista UNESP, Dept Microbiol & Imunol, Botucatu, SP - Brazil

^[7] Adolfo Lutz Inst, Rua Rubens Arruda S-N, Quadra 06, BR-17015110 Bauru, SP - Brazil

• Document type: Review article
• Source: Mycopathologia; v. 183, n. 6, p. 941-949, DEC 2018.
• Web of Science Citations: 1

Abstract

Fusarium species have emerged as responsible for a broad spectrum of infections, including superficial, locally invasive and disseminated ones, especially in the hospital environment. Since there are few reports of invasive and disseminated fusariosis in children, the aim of this study was to report four cases of nosocomial infection caused by this microorganism in children with cancer hospitalized in a public children's hospital located in Brazil. Two of these patients were female and two were male. All patients presented febrile neutropenia, while three patients had acute lymphocytic leukemia and one patient had Wilms' tumor as underlying disease. In two cases, fungi were isolated from blood and identified as Fusarium oxysporum species complex after phenotypic and genotypic studies, while in two other cases fungi were isolated from skin biopsies and identified as Fusarium solani species complex. One patient died 12days after the onset of cutaneous lesions. All isolates, after susceptibility testing, presented high levels of minimum inhibitory concentration for itraconazole, voriconazole and amphotericin B. Considering the emergence of filamentous fungi as etiologic agents of nosocomial infections, health professionals should be aware of the problems these infections, especially fungal ones, may cause to debilitated patients. (AU)

• FAPESP's process: 14/16507-0 - Monitoring nosocomial infection caused by Candida in west region of the State of São Paulo: phenotypic and genotypic characterizations and correlation with the risk factors in patients with cancer
• Grantee: Luciana da Silva Ruiz Menezes
• Support Opportunities: Regular Research Grants