| Full text | |
| Author(s): |
Saramago, Eduardo A.
[1]
;
Borges, Gabriela S.
[1]
;
Singolani-, Jr., Carlitos G.
[1]
;
Nogueira, Jonatas E.
[1, 2]
;
Soriano, Renato N.
[3]
;
Carnio, Evelin C.
[4]
;
Branco, Luiz G. S.
[5]
Total Authors: 7
|
| Affiliation: | [1] Univ Sao Paulo, Med Sch Ribeirao Preto, BR-14049900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Phys Educ & Sports Ribeirao Preto, BR-14030680 Ribeirao Preto, SP - Brazil
[3] Univ Fed Juiz de Fora, Div Physiol & Biophys, Dept Basic Life Sci, BR-35010177 Governador Valadares, MG - Brazil
[4] Univ Sao Paulo, Nursing Sch Ribeirao Preto, BR-14040902 Sao Paulo - Brazil
[5] Univ Sao Paulo, Dent Sch Ribeirao Preto, BR-14040904 Sao Paulo - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | BRAIN BEHAVIOR AND IMMUNITY; v. 75, p. 119-128, JAN 2019. |
| Web of Science Citations: | 6 |
| Abstract | |
Molecular hydrogen (H-2) exerts anti-oxidative, anti-apoptotic, and anti-inflammatory effects. Here we tested the hypothesis that H-2 modulates cardiovascular, inflammatory, and thermoregulatory changes in systemic inflammation (SI) induced by lipopolysaccharide (LPS) at different doses (0.1 or 1.5 mg/kg, intravenously, to induce mild or severe SI) in male Wistar rats (250-300 g). LPS or saline was injected immediately before the beginning of 360-minute inhalation of H-2 (2% H-2, 21% O-2, balanced with nitrogen) or room air (21% O-2, balanced with nitrogen). Deep body temperature (Tb) was measured by dataloggers pre-implanted in the peritoneal cavity. H-2 caused no change in cardiovascular, inflammatory parameters, and Tb of control rats (treated with saline). During mild SI, H-2 reduced plasma surges of proinflammatory cytokines (TNF-alpha and IL-6) while caused an increase in plasma IL-10 (anti-inflammatory cytokine) and prevented fever. During severe SI, H-2 potentiated hypothermia, and prevented fever and hypotension, which coincided with reduced plasma nitric oxide (NO) production. Moreover, H-2 caused a reduction in surges of proinflammatory cytokines (plasma TNF-alpha and IL-1 beta) and prostaglandin E-2 {[}(PGE(2)), in plasma and hypothalamus], and an increase in plasma IL-10. These data are consistent with the notion that H-2 blunts fever in mild SI, and during severe SI potentiates hypothermia, prevents hypotension reducing plasma NO production, and exerts anti-inflammatory effects strong enough to prevent fever by altering febrigenic signaling and ultimately down-modulating hypothalamic PGE(2) production. (AU) | |
| FAPESP's process: | 16/17681-9 - Pathophysiological changes during systemic inflammation |
| Grantee: | Luiz Guilherme de Siqueira Branco |
| Support Opportunities: | Research Projects - Thematic Grants |