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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

FGF-2 and FGFR-1 might be independent prognostic factors in oral tongue squamous cell carcinoma

Full text
Author(s):
Mariz, Bruno A. L. A. [1] ; Soares, Ciro D. [1] ; de Carvalho, Maria G. F. [2] ; Jorge-Junior, Jacks [1]
Total Authors: 4
Affiliation:
[1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba - Brazil
[2] Univ Potiguar, Dept Oral Pathol, Natal, RN - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Histopathology; v. 74, n. 2, p. 311-320, JAN 2019.
Web of Science Citations: 1
Abstract

Aims Fibroblast growth factor (FGF)-2 and fibroblast growth factor receptor (FGFR)-1 are associated with tumour invasiveness, cell proliferation, angiogenesis, and metastasis. The aims of this study were to investigate FGF-2 expression and FGFR-1 expression in oral epithelial dysplasia (OED) and oral tongue squamous cell carcinoma (OTSCC), and their correlation with OTSCC patients' prognosis. Methods and results One hundred and sixty-seven cases were retrospectively selected, including 85 surgical specimens of patients with OTSCC, 46 incisional biopsies of OTSCC, and 36 incisional biopsies of OED. Tissue sections were subjected to immunohistochemical staining for FGF-2 and FGFR-1, and digitally scored. Elevated scores of FGF-2 and FGFR-1 immunostaining were associated with high-grade OEDs. FGF-2 positivity in the stroma was associated with vascular invasion and a worse prognosis, in both overall survival (OS) and disease-free survival (DFS) analyses, in univariate and multivariate models. FGFR-1 positivity in the stroma was correlated with lymph node metastasis and distant metastasis. FGFR-1 expression in either the malignant cells or the stroma was strongly correlated with shorter OS and DFS. Conclusions Taken together, our findings suggest that increased FGF-2 expression and increased FGFR-1 expression are associated with high-grade OEDs, and are correlated with the presence of metastasis and adverse outcomes in OTSCC patients. (AU)

FAPESP's process: 17/16102-8 - Akt, COX-2, RUNX1 and MMPs expression in metastatic melanomas
Grantee:Jacks Jorge Junior
Support Opportunities: Regular Research Grants
FAPESP's process: 15/25905-1 - Akt, COX-2, RUNX1 and MMPs expression in metastatic melanomas and Biotechnology prospection of molecules with antineoplastic activity
Grantee:Ciro Dantas Soares
Support Opportunities: Scholarships in Brazil - Doctorate