Kaurenoic acid and its sodium salt derivative: antibacterial activity against Porphyromonas gingivalis and their mechanism of action

Author(s)

Martins, Carlos H. G. ^[1] ; Abrao, Fariza ^[1] ; Moraes, Thais S. ^[1] ; Oliveira, Pollyanna F. ^[2] ; Tavares, Denise C. ^[2] ; Magalhaes, Lizandra G. ^[3] ; Galvao, Fabio C. ^[4] ; Veneziani, Rodrigo C. S. ^[3] ; Ambrosio, Sergio R. ^[3]

Affiliation

^[1] Univ Franca UNIFRAN, Res Lab Appl Microbiol, BR-14404600 Franca, SP - Brazil

^[2] Univ Franca UNIFRAN, Lab Mutagenesis, BR-14404600 Franca, SP - Brazil

^[3] Univ Franca UNIFRAN, Nucl Res Sci & Technol, BR-14404600 Sao Paulo - Brazil

^[4] Sao Paulo State Univ UNESP, Dept Biol Sci, BR-14800901 Araraquara, SP - Brazil

• Document type: Journal article
• Source: FUTURE MICROBIOLOGY; v. 13, n. 14, p. 1585-1602, NOV 2018.
• Web of Science Citations: 0

Abstract

Aim: To evaluate the antibacterial activity of 12 kaurane-type diterpenes against a panel of bacteria that cause endodontic infection. Methods \& materials: We conducted tests against bacteria in the planktonic or in the sessile mode, cytotoxic assays for the most promising compounds against human normal lung fibroblast cells, and Porphyromonas gingivalis (ATCC 33277) proteomic analysis. Results \& conclusion: Kaurenoic acid and its salt exhibited satisfactory antibacterial action against the evaluated bacteria. Proteomic analysis suggested that these compounds might interfere in bacterial metabolism and virulence factor expression. Kaurane-type diterpenes are an important class of natural products and should be considered in the search for new irrigating solutions to treat endodontic infections. (AU)

• FAPESP's process: 12/25237-0 - Kaurane-type diterpenes: activity against anaerobic bacteria and proteomics
• Grantee: Carlos Henrique Gomes Martins
• Support Opportunities: Regular Research Grants