| Full text | |
| Author(s): |
Brisolla Tavares, Lais Calissi
[1, 2]
;
de Vasconcellos, Francielli Mahnic
[2]
;
de Sousa, William Vaz
[2]
;
Rocchetti, Taisa Trevizani
[3]
;
Mondelli, Alessandro Lia
[2]
;
Ferreira, Adriano Martison
[3]
;
Montelli, Augusto Cezar
[3]
;
Sadatsune, Terue
[3]
;
Tiba-Casas, Monique Ribeiro
[2]
;
Camargo, Carlos Henrique
[1, 2]
Total Authors: 10
|
| Affiliation: | [1] Univ Sao Paulo, Fac Med, Sao Paulo - Brazil
[2] Adolfo Lutz Inst, Ctr Bacteriol, Sao Paulo - Brazil
[3] Fac Med Botucatu, Botucatu, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | FRONTIERS IN MICROBIOLOGY; v. 9, JAN 4 2019. |
| Web of Science Citations: | 2 |
| Abstract | |
Dissemination of carbapenem-resistant Acinetobacter baumannii is currently one of the priority themes discussed around the world, including in Brazil, where this pathogen is considered endemic. A total of 107 carbapenem-resistant A. baumannii (CRAB) isolates were collected from patients with bacteraemia attended at a teaching hospital in Brazil from 2008 to 2014. From these samples, 104 (97.2%) carried bla(OXA-23-like), all of them associated with ISAba1 The bla(OXA-231) (1.9%) and bla(OXA-72) (0.9%) genes were also detected in low frequencies. All isolates were susceptible to minocycline, and 38.3% of isolates presented intermediate susceptibility to tigecycline (MIC = 4 mu g/ml). Molecular typing assessed by multi-locus sequence typing demonstrated that the strains were mainly associated with clonal complexes CC79 (47.4%), followed by CC1 (16.9%), and CC317 (18.6%), belonging to different pulsotypes and in different prevalences over the years. Changes in the clones' prevalence reinforce the need of identifying and controlling CRAB in hospital settings to preserve the already scarce therapeutic options available. (AU) | |
| FAPESP's process: | 15/13179-4 - Genetic diversity and antimicrobial susceptibility profile of multidrug-resistant strains of Acinetobacter calcoaceticus-A. baumannii complex in a teaching hospital |
| Grantee: | Laís Calissi Brisolla Tavares |
| Support Opportunities: | Scholarships in Brazil - Master |