| Full text | |
| Author(s): |
Total Authors: 4
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| Affiliation: | [1] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Sao Paulo - Brazil
Total Affiliations: 1
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| Document type: | Review article |
| Source: | FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY; v. 6, AUG 28 2018. |
| Web of Science Citations: | 8 |
| Abstract | |
The blastocyst inner cell mass (ICM) that gives rise to a whole embryo in vivo can be derived and cultured in vitro as embryonic stem cells (ESCs), which retain full developmental potential. ICM cells receive, from diverse sources, complex molecular and spatiotemporal signals that orchestrate the finely-tuned processes associated with embryogenesis. Those instructions come, continuously, from themselves and from surrounding cells, such as those present in the trophectoderm and primitive endoderm (PrE). A key component of the ICM niche are the extracellular vesicles (EVs), produced by distinct cell types, that carry and transfer key molecules that regulate target cells and modulate cell renewal or cell fate. A growing number of studies have demonstrated the extracellular circulation of morphogens, a group of classical regulators of embryo development, are carried by EVs. miRNAs are also an important cargo of the EVs that have been implicated in tissue morphogenesis and have gained special attention due to their ability to regulate protein expression through post-transcriptional modulation, thereby influencing cell phenotype. This review explores the emerging evidence supporting the role of EVs as an additional mode of intercellular communication in early embryonic and ESCs differentiation. (AU) | |
| FAPESP's process: | 17/20271-0 - Role of prion protein in the dynamic of multiprotein signaling modules related to stemness of glioblastoma stem cells: its functional role and potential therapeutic target |
| Grantee: | Marilene Hohmuth Lopes |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 14/17385-5 - Impact of the depletion of the co-chaperone STI1 in the control of pluripotency, proliferation and differentiation of murine embryonic stem cells |
| Grantee: | Jenny Andrea Arévalo Romero |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 13/19860-0 - Study of PrPc and STI1 interaction in human glioblastoma stem cells in vivo |
| Grantee: | Rebeca Piatniczka Iglesia |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 11/13906-2 - Contribution of the co-chaperone STI1 in mouse development: embryonic stem cell as approach |
| Grantee: | Marilene Hohmuth Lopes |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 13/22078-1 - Profile of extracellular vesicles miRNA in the neuronal differentiation of murine embryonic stem cells |
| Grantee: | Lilian Cruz |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |