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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Sleeping Beauty and the Microenvironment Enchantment: Microenvironmental Regulation of the Proliferation-Quiescence Decision in Normal Tissues and in Cancer Development

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Author(s):
Zen Petisco Fiore, Ana Paula [1] ; Ribeiro, Pedro de Freitas [1] ; Bruni-Cardoso, Alexandre [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, E Signal Lab, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY; v. 6, JUN 7 2018.
Web of Science Citations: 5
Abstract

Cells from prokaryota to the more complex metazoans cease proliferating at some point in their lives and enter a reversible, proliferative-dormant state termed quiescence. The appearance of quiescence in the course of evolution was essential to the acquisition of multicellular specialization and compartmentalization and is also a central aspect of tissue function and homeostasis. But what makes a cell cease proliferating even in the presence of nutrients, growth factors, and mitogens? And what makes some cells ``wake up{''} when they should not, as is the case in cancer? Here, we summarize and discuss evidence showing how microenvironmental cues such as those originating from metabolism, extracellular matrix (ECM) composition and arrangement, neighboring cells and tissue architecture control the cellular proliferation-quiescence decision, and how this complex regulation is corrupted in cancer. (AU)

FAPESP's process: 17/18067-5 - Investigation of the dynamics and function of nuclear actin in response to different mechanical signals and composition of the extracellular matrix
Grantee:Pedro de Freitas Ribeiro
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 14/25832-1 - Hippo-YAP pathway as a mediator of extracellular matrix signals in non-malignant and malignant epithelial cells of the mammary gland
Grantee:Ana Paula Zen Petisco Fiore
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 14/10492-0 - Hippo-YAP as a converging pathway for biochemical and mechanical signals from the extracellular matrix during mammary gland morphogenesis and breast cancer progression
Grantee:Alexandre Bruni Cardoso
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 17/18641-3 - MST2 proteolysis as a mechanism to modulate HIPPO-YAP activity in breast epithelial cells
Grantee:Ana Paula Zen Petisco Fiore
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor