Dataset for the role of sustained attention in memory formation of transgenic mice for Alzheimer's disease

Author(s)

Schowe, Natalia Mendes ^[1] ; de Oliveira, Eduardo Moreira ^[2] ; Buck, Hudson Sousa ^[3] ; Viel, Tania Araujo ^{[4, 1]}

Affiliation

^[1] Univ Sao Paulo, Inst Biomed Sci, Grad Course Pharmacol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, Dept Cognit Neurol, Grad Course Neurol, Sao Paulo - Brazil

^[3] Santa Casa Sao Paulo Sch Med Sci, Dept Physiol Sci, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Sch Arts Sci & Humanities, Sao Paulo - Brazil

• Document type: Journal article
• Source: DATA IN BRIEF; v. 6, p. 763-768, MAR 2016.
• Web of Science Citations: 0

Abstract

Weekly submission of rats to active avoidance apparatus can be considered a neurostimulation strategy, once it can improve memory and can increase the density of receptors from different neurotransmitter systems in brain areas related to memory. These benefits were observed in rats chronically infused with amyloid-beta peptide. In the present work it is presented that the same benefit for memory was observed in five months old transgenic mice for Alzheimers disease (TG-PDGFB-APP(Sw,Ind)). However, at this age, no change in density of nicotinic receptors was observed. (C) 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CCBY license. (AU)

• FAPESP's process: 07/07433-9 - Evaluation of the nicotinic cholinergic neuroplasticity at the amygdala, after cognitive stimulation, in an animal model of neurodegeneration and in aging
• Grantee: Tânia Araújo Viel
• Support Opportunities: Regular Research Grants
• FAPESP's process: 09/15973-9 - Influence of cognitive stimulation on central cholinergic system of transgenic mice for Alzheimer's disease
• Grantee: Natália Mendes Schowe
• Support Opportunities: Scholarships in Brazil - Scientific Initiation