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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Recent applications of magnesium- and Zinc-TMP amides in the synthesis of bioactive targets

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Author(s):
Nishimura, Rodolfo H. V. [1, 2] ; Vaz, Artur de L. L. [2] ; Bozzini, Leandro A. [2] ; Murie, Valter E. [2] ; Clososki, Giuliano C. [1, 2]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, Av Bandeirantes 3900, BR-14040901 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Nucleo Pesquisa Prod Nat & Sintet, Av Cafe S-N, BR-14040903 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Tetrahedron; v. 75, n. 4, p. 464-474, JAN 25 2019.
Web of Science Citations: 1
Abstract

Magnesium- and zinc-TMP amides have come out from relative obscurity to be recognized as important tools in modern synthetic chemistry. Development of LiCl-activated metal amides like TMPMgCl center dot LiCl and TMP2Zn center dot 2MgCl(2)center dot 2LiCl has been important to obtain new organometallic reagents through highly chemo-and regioselective reactions. Herein, we review how these reagents are applied in the synthesis of important bioactive targets such as natural products and drugs. (C) 2018 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 15/01466-9 - Directed functionalization of quinazolines and quinazolinones aiming the synthesis of bioactive substances
Grantee:Rodolfo Hideki Vicente Nishimura
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/21364-6 - Applicantion of organometallic reagents in the directed functionalization of quinolines aimming the synthesis of medicinal interest compounds
Grantee:Valter Eduardo Murie
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/12718-1 - Application and development of continuous flow processes in the synthesis of fentanylic opioids
Grantee:Artur de Lara Lima Vaz
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 18/14150-8 - Selective aromatic functionalization: Methodological Studies and new applications in the synthesis of BIOATIVE compounds
Grantee:Giuliano Cesar Clososki
Support type: Regular Research Grants