Recent applications of magnesium- and Zinc-TMP amides in the synthesis of bioactive targets

Author(s)

Nishimura, Rodolfo H. V. ^{[1, 2]} ; Vaz, Artur de L. L. ^[2] ; Bozzini, Leandro A. ^[2] ; Murie, Valter E. ^[2] ; Clososki, Giuliano C. ^{[1, 2]}

Affiliation

^[1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, Av Bandeirantes 3900, BR-14040901 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Nucleo Pesquisa Prod Nat & Sintet, Av Cafe S-N, BR-14040903 Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: Tetrahedron; v. 75, n. 4, p. 464-474, JAN 25 2019.
• Web of Science Citations: 1

Abstract

Magnesium- and zinc-TMP amides have come out from relative obscurity to be recognized as important tools in modern synthetic chemistry. Development of LiCl-activated metal amides like TMPMgCl center dot LiCl and TMP2Zn center dot 2MgCl(2)center dot 2LiCl has been important to obtain new organometallic reagents through highly chemo-and regioselective reactions. Herein, we review how these reagents are applied in the synthesis of important bioactive targets such as natural products and drugs. (C) 2018 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 16/12718-1 - Application and development of continuous flow processes in the synthesis of fentanylic opioids
• Grantee: Artur de Lara Lima Vaz
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 15/21364-6 - Applicantion of Organometallic Reagents in the Directed Functionalization of Quinolines Aimming the Synthesis of Medicinal Interest Compounds
• Grantee: Valter Eduardo Murie
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 15/01466-9 - Directed functionalization of quinazolines and quinazolinones aiming the synthesis of bioactive substances
• Grantee: Rodolfo Hideki Vicente Nishimura
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 18/14150-8 - Selective aromatic functionalization: Methodological Studies and new applications in the synthesis of BIOATIVE compounds
• Grantee: Giuliano Cesar Clososki
• Support Opportunities: Regular Research Grants