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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Insulin favors acute inflammatory reaction in alloxan-diabetic tilapia during infectious aerocystitis

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Author(s):
Prado, Ed Johnny R. [1] ; Belo, Marco Antonio A. [2, 1] ; Moraes, Alessandra C. [1] ; Barbuio, Roberto [1] ; Foz, Elizabeth P. [2] ; Faria, Vanessa P. [2] ; Sebastiao, Fernanda A. [3]
Total Authors: 7
Affiliation:
[1] Univ Estadual Paulista Julio de Mesquita Filho Un, FCAV, Campus Jaboticabal, BR-14884900 Jaboticabal, SP - Brazil
[2] Univ Brasil, Ave Hilario da Silva Passos 950, BR-13690000 Descalvado, SP - Brazil
[3] Univ Estadual Paulista Julio de Mesquita Filho Un, Ctr Aquicultura, Via Acesso Prof Paulo Donato Castellane S-N, BR-14884900 Jaboticabal, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Pesquisa Veterinária Brasileira; v. 38, n. 12, p. 2190-2193, DEC 2018.
Web of Science Citations: 1
Abstract

ABSTRACT: In vertebrates, the inflammatory reaction is responsible for modulating the initial nonspecific defense until specific immunity is acquired. In this context, numerous studies in mammals have demonstrated the participation of insulin in the inflammatory response, favoring cell proliferation and the migratory capacity of endothelial cells, vascular smooth muscle cells and monocytes, as well as mediating the expression of pro-thrombotic and pro-fibrotic factors. However, little is known about the effect of this peptidic hormone on the inflammatory reaction in teleostean fish. In order to evaluate the participation of insulin in the acute inflammatory response of Nile tilapia, Oreochromis niloticus, during aerocystitis induced by Aeromonas hydrophila, and 48 aloxane-diabetic tilapia were used, constituting two groups: diabetics treated with insulin and diabetics without treatment. After six, 24, and 48 hours of inflammatory stimulation, tilapia were submitted to deep anesthesia for euthanasia and necropsy, and thus, obtaining exudate and harvesting of the swim bladder for analysis of the inflammatory reaction. Based on this premise, the present study demonstrated the participation of insulin in the acute inflammatory reaction of alloxan-diabetic tilapia by favors the cellular accumulation in the exudate, the proliferative effect of fibrous tissue and neovascularization in the inflamed site. Such findings reinforce the old hypothesis that insulin plays an important role in the innate immune response during acute inflammatory reaction, being an important pro-inflammatory hormone. However, Nile tilapia proved to be a promising experimental model for studies and advances in research involving diabetes mellitus. (AU)

FAPESP's process: 11/16945-9 - Study of the involvement of insulin and exogenous glucocorticoid on acute inflammatory response of Nile tilapia, Oreochromis niloticus, challenged with Aeromonas hydrophila.
Grantee:Ed Johnny da Rosa Prado
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 12/12256-7 - Study of the involvement of insulin and exogenous glucocorticoid on acute inflammatory response of Nile tilapia, Oreochromis niloticus, challenged with Aeromonas hydrophila.
Grantee:Marco Antonio de Andrade Belo
Support Opportunities: Regular Research Grants