Advanced search
Start date
Betweenand
(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Histopathological aspects of renal lesions in cats experimentally infected with feline immunodeficiency virus

Full text
Author(s):
Leonardo P. Mesquita [1] ; Denise Haibara [2] ; Marcelo S. Zanutto [3] ; Lilian R.M. de Sá [4] ; Mitika K. Hagiwara [5] ; Paulo C. Maiorka [6]
Total Authors: 6
Affiliation:
[1] Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia. Departamento de Patologia - Brasil
[2] Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia. Departamento de Patologia - Brasil
[3] Universidade Estadual de Londrina. Centro de Ciências Agrárias. Departamento de Clínicas Veterinárias - Brasil
[4] Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia. Departamento de Patologia - Brasil
[5] USP. FMVZ. Departamento de Clínica Médica
[6] Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia. Departamento de Patologia - Brasil
Total Affiliations: 6
Document type: Journal article
Source: Pesquisa Veterinária Brasileira; v. 34, n. 9, p. 869-873, 2014-09-00.
Abstract

The feline immunodeficiency virus (FIV) infection in domestic cats is characterized by immunological disorders that commonly manifest in a later stage of the disease. Similarly to the human immunodeficiency virus (HIV) infection in humans, FIV infection is commonly associated with opportunistic infections and progressive development of nephropathies. Therefore, the aim of the present study was to perform histological evaluation of the kidneys of 10 cats experimentally infected with FIV and euthanized at 60 months after viral inoculation. In the kidneys of 100% of the cats infected with FIV, glomerular and tubulointerstitial lesions were seen. The glomerular lesions were mainly characterized by global or segmental thickening of the glomerular basement membrane (membranous glomerulonephritis). Glomerulosclerosis, and in two cases, proliferation of intraglomerular epithelial cells (glomerular crescent) were also observed. The intersticial lymphoplasmacytic nephritis was the tubulointerstitial alteration most frequent and was observed in different intensity levels in 100% of the cats. The results of the present study demonstrate that the prolonged time between infection and histopathological evaluation may have been decisive for the arising of renal lesions in all cats infected with FIV and for the increase of these lesions in some cats. (AU)