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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The antimicrobial potential of Streptomyces from insect microbiomes

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Author(s):
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Chevrette, Marc G. [1, 2] ; Carlson, Caitlin M. [1] ; Ortega, Humberto E. [3] ; Thomas, Chris [4] ; Ananiev, Gene E. [5] ; Barns, Kenneth J. [4] ; Book, Adam J. [1] ; Cagnazzo, Julian [1] ; Carlos, Camila [1] ; Flanigan, Will [1] ; Grubbs, Kirk J. [1] ; Horn, Heidi A. [1] ; Hoffmann, F. Michael [5] ; Klassen, Jonathan L. [6] ; Knack, Jennifer J. [7] ; Lewin, Gina R. [8] ; McDonald, Bradon R. [1] ; Muller, Laura [1] ; Melo, Weilan G. P. [3] ; Pinto-Tomas, Adrian A. [9, 10] ; Schmitz, Amber [1] ; Wendt-Pienkowski, Evelyn [1] ; Wildman, Scott [4] ; Zhao, Miao [11] ; Zhang, Fan [4] ; Bugni, Tim S. [4] ; Andes, David R. [11] ; Pupo, Monica T. [3] ; Currie, Cameron R. [1]
Total Authors: 29
Affiliation:
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[1] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 - USA
[2] Univ Wisconsin, Genet Lab, Madison, WI 53706 - USA
[3] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil
[4] Univ Wisconsin, Sch Pharm, Pharmaceut Sci Div, Madison, WI 53705 - USA
[5] Univ Wisconsin, Wisconsin Inst Med Res, McArdle Lab Canc Res, Madison, WI 53705 - USA
[6] Univ Connecticut, Dept Mol & Cell Biol, Storrs, CT 06269 - USA
[7] Univ Minnesota, Dept Biol, Large Lakes Observ, Duluth, MN 55812 - USA
[8] Georgia Inst Technol, Sch Biol Sci, Atlanta, GA 30332 - USA
[9] Univ Costa Rica, Sch Med, Ctr Res Microscop Struct, San Jose 10102 - Costa Rica
[10] Univ Costa Rica, Sch Med, Dept Biochem, San Jose 10102 - Costa Rica
[11] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Madison, WI 53705 - USA
Total Affiliations: 11
Document type: Journal article
Source: NATURE COMMUNICATIONS; v. 10, JAN 31 2019.
Web of Science Citations: 16
Abstract

Antimicrobial resistance is a global health crisis and few novel antimicrobials have been discovered in recent decades. Natural products, particularly from Streptomyces, are the source of most antimicrobials, yet discovery campaigns focusing on Streptomyces from the soil largely rediscover known compounds. Investigation of understudied and symbiotic sources has seen some success, yet no studies have systematically explored microbiomes for antimicrobials. Here we assess the distinct evolutionary lineages of Streptomyces from insect microbiomes as a source of new antimicrobials through large-scale isolations, bioactivity assays, genomics, metabolomics, and in vivo infection models. Insect-associated Streptomyces inhibit antimicrobial-resistant pathogens more than soil Streptomyces. Genomics and metabolomics reveal their diverse biosynthetic capabilities. Further, we describe cyphomycin, a new molecule active against multidrug resistant fungal pathogens. The evolutionary trajectories of Streptomyces from the insect microbiome influence their biosynthetic potential and ability to inhibit resistant pathogens, supporting the promise of this source in augmenting future antimicrobial discovery. (AU)

FAPESP's process: 14/14095-6 - Bacterial symbionts isolated from fungus-growing ants collected in remaining hotspots of biodiversity in São Paulo State as sources of antiparasitic compounds
Grantee:Humberto Enrique Ortega Dominguez
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 15/01001-6 - Discovering bacterial symbionts diversity associated with ants in different Brazilian biomes
Grantee:Weilan Gomes da Paixão Melo
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 13/50954-0 - Novel therapeutic agents from the bacterial symbionts of Brazilian invertebrates
Grantee:Mônica Tallarico Pupo
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants