Advanced search
Start date
Betweenand

Bacterial symbionts isolated from fungus-growing ants collected in remaining hotspots of biodiversity in São Paulo State as sources of antiparasitic compounds

Grant number: 14/14095-6
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): August 01, 2014
Effective date (End): December 31, 2018
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Cooperation agreement: National Institutes of Health (NIH)
Principal Investigator:Mônica Tallarico Pupo
Grantee:Humberto Enrique Ortega Dominguez
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:13/50954-0 - Novel therapeutic agents from the bacterial symbionts of Brazilian invertebrates, AP.BTA.TEM
Associated scholarship(s):16/20154-0 - Exploring antimicrobial, anticancer and antiparasitic compounds from bacterial symbionts isolated from Acromyrmex ants, collected in São Paulo State, Brazil, BE.EP.DD

Abstract

This Doctorate (DD) fellowship will give graduate student the opportunity to develop his/her research in different topics of the entire ICBG project, from insect collection to natural product identification. Insect collections will be in the Vassununga State Park, SP, which still houses remaining areas of Atlantic Forest and Cerrado in São Paulo State. Bacterial strains will be isolated and preserved, and further cultured for extracts preparation. Extracts will be evaluated in the ICBG primary assays and antiparasitic hits (Chagas' disease and leishmaniasis) will be selected for further chemical studies aiming the identification of new natural products useful for therapeutical development. (AU)

Matéria(s) publicada(s) na Agência FAPESP sobre a bolsa:
Compound that kills drug-resistant fungi is isolated from ant microbiota 
Articles published in other media outlets: (1 total)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ORTEGA, HUMBERTO E.; BATISTA, JR., JOAO M.; MELO, WEILAN G. P.; DE PAULA, GABRIELA T.; PUPO, MONICA T. Structure and Absolute Configuration of Secondary Metabolites from Two Strains of Streptomyces chartreusis Associated with Attine Ants. Journal of the Brazilian Chemical Society, v. 30, n. 12, SI, p. 2672-2680, DEC 2019. Web of Science Citations: 0.
ORTEGA, HUMBERTO E.; FERREIRA, LEONARDO L. G.; MELO, WEILAN G. P.; OLIVEIRA, ANA LIGIA L.; RAMOS ALVARENGA, RENE F.; LOPES, NORBERTO P.; BUGNI, TIM S.; ANDRICOPULO, ADRIANO D.; PUPO, MONICA T. Antifungal compounds from Streptomyces associated with attine ants also inhibit Leishmania donovani. PLoS Neglected Tropical Diseases, v. 13, n. 8 AUG 2019. Web of Science Citations: 0.
CHEVRETTE, MARC G.; CARLSON, CAITLIN M.; ORTEGA, HUMBERTO E.; THOMAS, CHRIS; ANANIEV, GENE E.; BARNS, KENNETH J.; BOOK, ADAM J.; CAGNAZZO, JULIAN; CARLOS, CAMILA; FLANIGAN, WILL; GRUBBS, KIRK J.; HORN, HEIDI A.; HOFFMANN, F. MICHAEL; KLASSEN, JONATHAN L.; KNACK, JENNIFER J.; LEWIN, GINA R.; MCDONALD, BRADON R.; MULLER, LAURA; MELO, WEILAN G. P.; PINTO-TOMAS, ADRIAN A.; SCHMITZ, AMBER; WENDT-PIENKOWSKI, EVELYN; WILDMAN, SCOTT; ZHAO, MIAO; ZHANG, FAN; BUGNI, TIM S.; ANDES, DAVID R.; PUPO, MONICA T.; CURRIE, CAMERON R. The antimicrobial potential of Streptomyces from insect microbiomes. NATURE COMMUNICATIONS, v. 10, JAN 31 2019. Web of Science Citations: 16.
HUMBERTO E. ORTEGA; JOÃO M. BATISTA JR.; WEILAN G. P. MELO; GABRIELA T. DE PAULA; MÔNICA T. PUPO. Structure and Absolute Configuration of Secondary Metabolites from Two Strains of Streptomyces chartreusis Associated with Attine Ants. Journal of the Brazilian Chemical Society, v. 30, n. 12, p. 2672-2680, Dez. 2019.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.