| Full text | |
| Author(s): |
Simone M.R. Santos
[1]
;
Thalita L. Ferreira
[2]
;
Virgínia S. Quintal
[3]
;
Solange B. Carbonare
[4]
;
Milene Tino-De-Franco
[5]
Total Authors: 5
|
| Affiliation: | [1] Instituto Butantan. Laboratório de Imunogenética - Brasil
[2] Instituto Butantan. Laboratório de Imunogenética - Brasil
[3] Universidade de São Paulo. Hospital Universitário. Banco de Leite Humano
[4] Instituto Butantan. Laboratório de Imunogenética - Brasil
[5] Instituto Butantan. Laboratório de Imunogenética - Brasil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | Jornal de Pediatria; v. 89, n. 5, p. 510-513, 2013-10-00. |
| Abstract | |
OBJECTIVE: To verify the presence of anti-rotavirus serotype G9P[5] SIgA and the virus neutralization capacity of milk samples from Brazilian women. METHODS: SIgA antibody levels reactive to rotavirus G9 were determined in 30 maternal milk samples by enzyme-linked immunosorbent assay (ELISA) using purified virus suspensions. The samples' capacity to neutralize rotavirus G9P[5] was analyzed using the MA-104 cells neutralization assay. RESULTS: Great individual variations were observed regarding the SIgA levels and neutralization titers, but all samples showed some G9P[5] neutralizing ability. A highly significant positive correlation was observed between antibody levels and neutralization titers. CONCLUSIONS: The high correlation between anti-rotavirus antibody levels and neutralizing capacity of the milk samples suggests a possible protective role of these antibodies against infection. These results also support the encouragement of the breast-feeding practice. (AU) | |