| Full text | |
| Author(s): |
Aída de Fátima Thomé Barbosa Gouvêa
[1]
;
Maria Isabel de Moraes Pinto
[2]
;
Maristela Miyamoto
[3]
;
Daisy Maria Machado
[4]
;
Silvana Duarte Pessoa
[5]
;
Fabiana Bononi do Carmo
[6]
;
Suênia Cordeiro de Vasconcelos Beltrão
[7]
;
Regina Célia de Menezes Succi
[8]
Total Authors: 8
|
| Affiliation: | [1] Universidade Federal de São Paulo. Escola Paulista de Medicina - Brasil
[2] Universidade Federal de São Paulo. Escola Paulista de Medicina - Brasil
[3] Universidade Federal de São Paulo. Escola Paulista de Medicina - Brasil
[4] Universidade Federal de São Paulo. Escola Paulista de Medicina - Brasil
[5] Centro de Referência de DST. Ambulatório de Infectologia Pediátrica - Brasil
[6] Universidade Federal de São Paulo. Escola Paulista de Medicina - Brasil
[7] Universidade Federal de São Paulo. Escola Paulista de Medicina - Brasil
[8] Universidade Federal de São Paulo. Escola Paulista de Medicina - Brasil
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | Revista Paulista de Pediatria; v. 33, n. 2, p. 142-149, 2015-06-00. |
| Abstract | |
OBJECTIVE: To assess possible factors associated with the loss of antibodies to hepatitis A 7 years after the primary immunization in children of HIV-infected mothers and the response to revaccination in patients seronegative for hepatitis A. METHODS: Quantification of HAV antibodies by electrochemiluminescence was performed in 39 adolescents followed up at the Pediatric Aids Clinic of Federal University of São Paulo (Unifesp): 29 HIV-infected (HIV group) (median age: 12.8 years) and 10 HIV-exposed but non-infected (ENI group) (median age: 13.4 years). All of them received two doses of HAV vaccine (Havrix(r)) in 2002. RESULTS: The median age at primary immunization (PI) was 5.4 years for HIV group and 6.5 years for ENI group. All children, from both groups, had antibodies to HAV >20 mIU/mL after PI. Seven years later, the ENI group showed a median concentration of antibodies = 253.5 mIU/mL, while the HIV group = 113.0 mIU/mL (Mann-Whitney test, p=0.085). All ENI group and 23/29 (79.3%) from HIV group mantained HAV antibodies 7 years after PI. The levels of hepatitis A antibodies in the primary vaccination were the only factor independently associated with maintaining these antibodies for 7 years. The group that lost HAV seropositivity was revaccinated and 83.3% (5/6) responded with antibodies >20 mUI/mL. CONCLUSIONS: The antibodies levels acquired in the primary vaccination in the HIV group were the main factor associated with antibodies loss after HAV immunization. (AU) | |
| FAPESP's process: | 09/17275-7 - Dinamic of antibodies against hepatitis A virus (HAV) in HIV-infected and HIV-exposed uninfected children and its association with lymphocyte immunophenotyping six to eight years after immunization |
| Grantee: | Regina Célia de Menezes Succi |
| Support Opportunities: | Regular Research Grants |