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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Adherence to HeLa cells, typing by killer toxins and susceptibility to antifungal agents of Candida dubliniensis strains

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Author(s):
Gismari Miranda da Silva [1] ; Fernando Ricardo Xavier da Silveira [2] ; Maria de Fátima Costa Pires [3]
Total Authors: 3
Affiliation:
[1] University of São Paulo. School of Dentistry. Department of Stomatology
[2] University of São Paulo. School of Dentistry. Department of Stomatology
[3] Adolfo Lutz Institute
Total Affiliations: 3
Document type: Journal article
Source: Brazilian Oral Research; v. 21, n. 1, p. 87-91, 2007-03-00.
Abstract

The aim of this study was to evaluate the adherence capability to HeLa cells, the susceptibility to killer toxins and the in vitro susceptibility to antifungal agents (eTest? method - AB Biodisk, Solna, Sweden) of 9 Candida dubliniensis isolates recovered from HIV+ and AIDS patients. The adherence test was strongly positive for strain ATCC 777 and positive for all other strains. Typing by killer toxins revealed two different biotypes among the 9 isolates studied: 888 and 688. Only biotype 688 (ATCC 777) was susceptible to the K2 toxin. There was a significant inverse correlation between adherence and killer toxin susceptibility (r = -0.8525 - p = 0.0035). No strains presented resistance to fluconazole, itraconazole, ketoconazole, voriconazole, flucytosine or amphotericin-B. With the exception of ATCC 777, all the other isolates presented similar behavior. (AU)