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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Atrial natriuretic factor: is it responsible for hyponatremia and natriuresis in neurosurgery?

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Author(s):
Ana Paula Devite Cardoso Gasparotto [1] ; Antonio Luis Eiras Falcão [2] ; Carolina Kosour [3] ; Sebastião Araújo [4] ; Eliane Araújo Cintra [5] ; Rosmari Aparecida Rosa Almeida de Oliveira [6] ; Luiz Claudio Martins [7] ; Desanka Dragosavac [8]
Total Authors: 8
Affiliation:
[1] Universidade Estadual de Campinas. Faculdade de Medicina. Departamento de Cirurgia - Brasil
[2] Universidade Estadual de Campinas. Faculdade de Medicina. Departamento de Cirurgia - Brasil
[3] Universidade Estadual de Campinas. Faculdade de Medicina. Departamento de Cirurgia - Brasil
[4] Universidade Estadual de Campinas. Faculdade de Medicina. Departamento de Cirurgia - Brasil
[5] Universidade Estadual de Campinas. Faculdade de Medicina. Departamento de Enfermagem - Brasil
[6] Pontifícia Universidade Católica de Campinas. Departamento de Fisioterapia - Brasil
[7] Universidade Estadual de Campinas. Faculdade de Medicina. Departamento de Cirurgia - Brasil
[8] Universidade Estadual de Campinas. Faculdade de Medicina. Departamento de Cirurgia - Brasil
Total Affiliations: 8
Document type: Journal article
Source: Revista Brasileira de Terapia Intensiva; v. 28, n. 2, p. 154-160, 2016-06-00.
Abstract

ABSTRACT Objective: To evaluate the presence of hyponatremia and natriuresis and their association with atrial natriuretic factor in neurosurgery patients. Methods: The study included 30 patients who had been submitted to intracranial tumor resection and cerebral aneurism clipping. Both plasma and urinary sodium and plasma atrial natriuretic factor were measured during the preoperative and postoperative time periods. Results: Hyponatremia was present in 63.33% of the patients, particularly on the first postoperative day. Natriuresis was present in 93.33% of the patients, particularly on the second postoperative day. Plasma atrial natriuretic factor was increased in 92.60% of the patients in at least one of the postoperative days; however, there was no statistically significant association between the atrial natriuretic factor and plasma sodium and between the atrial natriuretic factor and urinary sodium. Conclusion: Hyponatremia and natriuresis were present in most patients after neurosurgery; however, the atrial natriuretic factor cannot be considered to be directly responsible for these alterations in neurosurgery patients. Other natriuretic factors are likely to be involved. (AU)