Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients

Author(s)

JULIANA M. DE SOUZA ^[1] ; RENAN GALAVERNA ^[2] ; ALINE A.N. DE SOUZA ^[3] ; TIMOTHY J. BROCKSOM ^[4] ; JULIO C. PASTRE ^[5] ; RODRIGO O.M.A. DE SOUZA ^[6] ; KLEBER T. DE OLIVEIRA ^[7]

Affiliation

^[1] Federal University of São Carlos. Department of Chemistry - Brasil

^[2] University of Campinas. Institute of Chemistry - Brasil

^[3] Federal University of São Carlos. Department of Chemistry - Brasil

^[4] Federal University of São Carlos. Department of Chemistry - Brasil

^[5] University of Campinas. Institute of Chemistry - Brasil

^[6] Federal University of Rio de Janeiro. Institute of Chemistry - Brasil

^[7] Federal University of São Carlos. Department of Chemistry - Brasil

• Document type: Journal article
• Source: Anais da Academia Brasileira de Ciências; v. 90, n. 1, p. 1131-1174, 2018-00-00.

Abstract

ABSTRACT We present a comprehensive review of the advent and impact of continuous flow chemistry with regard to the synthesis of natural products and drugs, important pharmaceutical products and definitely responsible for a revolution in modern healthcare. We detail the beginnings of modern drugs and the large scale batch mode of production, both chemical and microbiological. The introduction of modern continuous flow chemistry is then presented, both as a technological tool for enabling organic chemistry, and as a fundamental research endeavor. This part details the syntheses of bioactive natural products and commercial drugs. (AU)

• FAPESP's process: 14/26378-2 - Development of methodologies and synthetic processes employing a new technological platform: micro and meso reactor assisted synthesis of natural products and derivatives with potential pharmacological activity
• Grantee: Júlio Cezar Pastre
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 11/13993-2 - Methodologies for the synthesis of bioactive terpenes
• Grantee: Timothy John Brocksom
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
• Grantee: Vanderlei Salvador Bagnato
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 14/25770-6 - New frontiers in cross-coupling reactions promoted by palladium: combining enantioselective catalysis, C-H activations, new materials and in flux reactions aiming at high efficiency and sustainability in synthetic processes
• Grantee: Carlos Roque Duarte Correia
• Support Opportunities: Research Projects - Thematic Grants