| Full text | |
| Author(s): Show less - |
Fabiano Pinheiro da Silva
[1]
;
Germano Preuhs Filho
[2]
;
Eduardo Finger
[3]
;
Hermes Vieira Barbeiro
[4]
;
Fernando Godinho Zampieri
[5]
;
Alessandra Carvalho Goulart
[6]
;
Francisco Torggler Filho
[7]
;
Nicolas Panajotopoulos
[8]
;
Irineu Tadeu Velasco
[9]
;
Jorge Kalil
[10]
;
Heraldo Possolo de Souza
[11]
;
Luiz Monteiro da Cruz Neto
[12]
;
Helcio Rodrigues
[13]
Total Authors: 13
|
| Affiliation: Show less - | [1] Universidade de Sao Paulo. Departamento de Emergencias Clinicas - Brasil
[2] Universidade de Sao Paulo. Instituto do Coracao. Departamento de Imunologia - Brasil
[3] Laboratorios Salomao Zoppi - Brasil
[4] Universidade de Sao Paulo. Departamento de Emergencias Clinicas - Brasil
[5] Universidade de Sao Paulo. Departamento de Emergencias Clinicas - Brasil
[6] Universidade de Sao Paulo. Departamento de Emergencias Clinicas - Brasil
[7] Universidade de Sao Paulo. Departamento de Emergencias Clinicas - Brasil
[8] Universidade de Sao Paulo. Instituto do Coracao. Departamento de Imunologia - Brasil
[9] Universidade de Sao Paulo. Departamento de Emergencias Clinicas - Brasil
[10] Universidade de Sao Paulo. Instituto do Coracao. Departamento de Imunologia - Brasil
[11] Universidade de Sao Paulo. Departamento de Emergencias Clinicas - Brasil
[12] Universidade de Sao Paulo. Departamento de Emergencias Clinicas - Brasil
[13] Universidade de Sao Paulo. Instituto do Coracao. Departamento de Imunologia - Brasil
Total Affiliations: 13
|
| Document type: | Journal article |
| Source: | Revista Brasileira de Terapia Intensiva; v. 25, n. 4, p. 284-289, 2013-12-00. |
| Abstract | |
Objective: The HLA haplotype has been associated with many autoimmune diseases, but no associations have been described in sepsis. This study aims to investigate the HLA system as a possible marker of genetic sepsis susceptibility. Methods: This is a prospective cohort study including patients admitted to an intensive care unit and healthy controls from a list of renal transplant donors. Patients with less 18 years of age; pregnant or HIV positive patients; those with metastatic malignancies or receiving chemotherapy; or with advanced liver disease; or with end-of-life conditions were excluded. The DNA was extracted from the whole blood and HLA haplotypes determined using MiliPlex® technology. Results: From October 2010 to October 2012, 1,121 patients were included (1,078 kidney donors, 20 patients admitted with severe sepsis and 23 with septic shock). HLA-A*31 positive subjects had increased risk of developing sepsis (OR 2.36, 95%CI 1.26-5.35). Considering a p value <0.01, no other significant association was identified. Conclusion: HLA-A*31 expression is associated to risk of developing sepsis. (AU) | |
| FAPESP's process: | 09/17731-2 - Markers of infection in critically ill patients |
| Grantee: | Fabiano Pinheiro da Silva |
| Support Opportunities: | Research Grants - Young Investigators Grants |