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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Production and extraction of carotenoids produced by microorganisms

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Mussagy, Cassamo Ussemane [1] ; Winterburn, James [2] ; Santos-Ebinuma, Valeria Carvalho [1] ; Brandao Pereira, Jorge Fernando [1]
Total Authors: 4
[1] Sao Paulo State Univ UNESP, Dept Bioproc & Biotechnol, Sch Pharmaceut Sci, Rodovia Araraquara Jau Km 01, BR-14800903 Araraquara, SP - Brazil
[2] Univ Manchester, Sch Chem Engn & Analyt Sci, Manchester, Lancs - England
Total Affiliations: 2
Document type: Review article
Source: Applied Microbiology and Biotechnology; v. 103, n. 3, p. 1095-1114, FEB 2019.
Web of Science Citations: 3

Carotenoids are a group of isoprenoid pigments naturally synthesized by plants and microorganisms, which are applied industrially in food, cosmetic, and pharmaceutical product formulations. In addition to their use as coloring agents, carotenoids have been proposed as health additives, being able to prevent cancer, macular degradation, and cataracts. Moreover, carotenoids may also protect cells against oxidative damage, acting as an antioxidant agent. Considering the interest in greener and sustainable industrial processing, the search for natural carotenoids has increased over the last few decades. In particular, it has been suggested that the use of bioprocessing technologies can improve carotenoid production yields or, as a minimum, increase the efficiency of currently used production processes. Thus, this review provides a short but comprehensive overview of the recent biotechnological developments in carotenoid production using microorganisms. The hot topics in the field are properly addressed, from carotenoid biosynthesis to the current technologies involved in their extraction, and even highlighting the recent advances in the marketing and application of microbial carotenoids. It is expected that this review will improve the knowledge and understanding of the most appropriate and economic strategies for a biotechnological production of carotenoids. (AU)

FAPESP's process: 14/16424-7 - Optimization and scale-up of liquid-liquid extraction process with ionic liquids (ILs) as a sustainable tool for the separation of the anti-leukemia biopharmaceutical L-asparaginase (ASPase)
Grantee:Jorge Fernando Brandão Pereira
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 14/01580-3 - Biotechnological process for the development of new natural colorants from microorganisms for industrial application
Grantee:Valéria de Carvalho Santos Ebinuma
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 14/19793-3 - Optimization and scale-up of novel Ionic-Liquid-based purification processes for recombinant green fluorescent protein produced by Escherichia coli "GFPurIL"
Grantee:Sandro Roberto Valentini
Support type: Regular Research Grants
FAPESP's process: 17/50303-0 - Sustainable citrus waste biorefining as a source of value added bioproducts
Grantee:Valéria de Carvalho Santos Ebinuma
Support type: Regular Research Grants