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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Long-term consequences of the absence of leptin signaling in early life

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Author(s):
Ramos-Lobo, Angela M. [1] ; Teixeira, Pryscila D. S. [1] ; Furigo, Isadora C. [1] ; Melo, Helen M. [2] ; Lyra e Silva, Natalia de M. [2, 3] ; De Felice, Fernanda G. [2] ; Donato, Jr., Jose [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo - Brazil
[2] Univ Fed Rio de Janeiro, Inst Med Biochem Leopoldo de Meis, Rio De Janeiro - Brazil
[3] Queens Univ, Dept Psychiat, Ctr Neurosci Studies, Kingston, ON - Canada
Total Affiliations: 3
Document type: Journal article
Source: eLIFE; v. 8, JAN 29 2019.
Web of Science Citations: 3
Abstract

Leptin regulates energy balance and also exhibits neurotrophic effects during critical developmental periods. However, the actual role of leptin during development is not yet fully understood. To uncover the importance of leptin in early life, the present study restored leptin signaling either at the fourth or tenth week of age in mice formerly null for the leptin receptor (LepR) gene. We found that some defects previously considered irreversible due to neonatal deficiency of leptin signaling, including the poor development of arcuate nucleus neural projections, were recovered by LepR reactivation in adulthood. However, LepR deficiency in early life led to irreversible obesity via suppression of energy expenditure. LepR reactivation in adulthood also led to persistent reduction in hypothalamic Pomc, Cartpt and Prlh mRNA expression and to defects in the reproductive system and brain growth. Our findings revealed that early defects in leptin signaling cause permanent metabolic, neuroendocrine and developmental problems. (AU)

FAPESP's process: 15/10992-6 - Investigation of metabolic programming through different approaches
Grantee:Jose Donato Junior
Support Opportunities: Regular Research Grants
FAPESP's process: 14/11752-6 - Study of leptin functions during intrauterine and childhood stages in mice
Grantee:Angela Maria Ramos Lobo
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 16/09679-4 - Central effects of growth hormone on energetic metabolism and glicemic control
Grantee:Isadora Clivatti Furigo
Support Opportunities: Scholarships in Brazil - Post-Doctoral