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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Recent advances in the use of carbon nanotubes as smart biomaterials

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Canuto de Menezes, Beatriz Rossi [1] ; Rodrigues, Karla Faquine [1] ; da Silva Fonseca, Beatriz Carvalho [1] ; Ribas, Renata Guimaraes [1] ; do Amaral Montanheiro, Thais Larissa [1] ; Thim, Gilmar Patrocinio [1]
Total Authors: 6
[1] ITA, Div Ciencias Fundamentais, Praca Marechal Eduardo Gomes 50, BR-12228970 Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: JOURNAL OF MATERIALS CHEMISTRY B; v. 7, n. 9, p. 1343-1360, MAR 7 2019.
Web of Science Citations: 9

Carbon nanotubes (CNTs) have remarkable mechanical, thermal, electronic, and biological properties due to their particular atomic structure made of graphene sheets that are rolled into cylindrical tubes. Due to their outstanding properties, CNTs have been used in several technological fields. Currently, the most prominent research area of CNTs focuses on biomedical applications, using these materials to produce hybrid biosensors, drug delivery systems, and high performance composites for implants. Although a great number of research studies have already shown the advantages of CNT- based biomedical devices, their clinical use for in vivo application has not been consummated. Concerns related to their toxicity, biosafety, and biodegradation still remain. The effect of CNTs on the human body and the ecosystem is not well established, especially due to the lack of standardization of toxicological tests, which generate contradictions in the results. CNTs' toxicity must be clarified to enable the medical use of these exceptional materials in the near future. In this review, we summarize recent advances in developing biosensors, drug delivery systems, and implants using CNTs as smart biomaterials to identify pathogens, load/ deliver drugs and enhance the mechanical and antimicrobial performance of implants. (AU)

FAPESP's process: 17/24873-4 - PHBV and hydroxybutyrate functionalized CNT nanocomposite: kinetic study of crystallization and correlation with mechanical properties
Grantee:Thaís Larissa do Amaral Montanheiro
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/17492-6 - Effect of CTN functionalization with alcenes of several sizes on the CNT/PEAD nanocomposites
Grantee:Gilmar Patrocínio Thim
Support type: Regular Research Grants
FAPESP's process: 17/02846-5 - AgVO3/PMMA Nanocomposites: Effect of functionalization with acrilamide on mechanical and antimicrobial properties
Grantee:Beatriz Rossi Canuto de Menezes Rodrigues
Support type: Scholarships in Brazil - Doctorate