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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chitosan microparticles embedded with multi-responsive poly(N-vinylcaprolactam-co-itaconic acid-co-ethylene-glycol dimethacrylate)-based hydrogel nanoparticles as a new carrier for delivery of hydrophobic drugs

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Author(s):
Fonseca, Jessica de Matos [1] ; Medeiros, Simone de Fatima [1] ; Alves, Gizelda Maria [1] ; dos Santos, Danilo Martins [2] ; Campana-Filho, Sergio Paulo [2] ; dos Santos, Amilton Martins [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, EEL, Dept Chem Engn, Lab Polymers, Engn Sch Lorena, Estr Municipal Campinho S-N, BR-12602810 Lorena, SP - Brazil
[2] Univ Sao Paulo, IQSC, Chem Inst Sao Carlos, Ave Trabalhador Sancarlense 400, POB 780, BR-13560790 Sao Carlos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: COLLOIDS AND SURFACES B-BIOINTERFACES; v. 175, p. 73-83, MAR 1 2019.
Web of Science Citations: 7
Abstract

In this paper, chitosan was used as protective agent for dual temperature-/pH-sensitive poly(N-vinylcaprolactam-co-itaconic acid-co-ethylene-glycol dimethacrylate)-based hydrogel nanoparticles (poly(NVCL-co-IA-co-EGDMA)) aiming avoid their undesirable colloidal destabilization at different conditions of body human tissues. Thus, poly(NVCL-co-IA-co-EGDMA) was embedded into chitosan and a new solid dispersion was prepared via spray-drying and ketoprofen was used as carrier. Two different sizes of hydrogel nanoparticles (120.6 rim and 185.9 nm) were evaluated and they exhibited a drug encapsulation efficiency of the 39.6% and 57.8%, respectively. The smaller nanoparticles showed to be faster for releasing of ketoprofen at pH 7.4 and 37 degrees C due to their larger surface area and higher swelling ability. Chitosan played a role of a secondary barrier for the ketoprofen diffusion, extending its release compared to hydrogel nanoparticles alone. Among two concentrations (40 wt% and 70 wt%) of hydrogel nanoparticles related to chitosan, the first one induced higher percentages of ketoprofen release: 74.2% against 64.6%. In addition, the interactions between chitosan matrix and poly(NVCL-co-IA-co-EGDMA) did not change the multi-responsive behavior of hydrogels, suggesting the chitosan was efficient for keeping integrity of nanoparticles hydrogels. Chitosan/poly(NVCL-co-IA-co-EGDMA) hybrid microparticles seems to be a promising new carrier for release of hydrophobic drugs, such as ketoprofen. (AU)

FAPESP's process: 14/08027-8 - Development of new systems for controlled drug delivery
Grantee:Amilton Martins dos Santos
Support Opportunities: Multi-user Equipment Program
FAPESP's process: 13/06987-1 - Development of new systems for controlled drug delivery
Grantee:Amilton Martins dos Santos
Support Opportunities: Regular Research Grants