Inflammatory profile of chronic apical periodontitis: a literature review

Author(s)

Braz-Silva, Paulo Henrique ^{[1, 2]} ; Bergamini, Mariana Lobo ^[2] ; Mardegan, Andressa Pinto ^[2] ; De Rosa, Catharina Simioni ^[2] ; Hasseus, Bengt ^[3] ; Jonasson, Peter ^[4]

Affiliation

^[1] Univ Sao Paulo, Inst Trop Med Sao Paulo, Lab Virol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Dent, Dept Stomatol, Div Gen Pathol, Sao Paulo - Brazil

^[3] Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral Med & Pathol, Gothenburg - Sweden

^[4] Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Endodontol, Medicinaregatan 12, S-41390 Gothenburg - Sweden

• Document type: Review article
• Source: ACTA ODONTOLOGICA SCANDINAVICA; v. 77, n. 3, p. 173-180, APR 3 2019.
• Web of Science Citations: 3

Abstract

Apical periodontitis caused by root canal infection is the most frequent pathological lesion in the jaws, mainly manifested as periapical granulomas and cysts. Understanding of the formation and progression of apical periodontitis as well as the identification of inflammatory biomarkers can help increase the knowledge of pathogenic mechanisms, improve the diagnosis and provide support for different therapeutic strategies. The objective of the present article is to review inflammatory biomarkers such as cytokines, chemokines, inflammatory cells, neuropeptides, RANK/RANKL/OPG system and other inflammatory markers and to relate these systems to the development and progression of pathological conditions related to apical periodontitis. (AU)

• FAPESP's process: 15/07727-9 - Evaluation of immunoregulatory microenvironment of oral premalignant lesions, squamous cell carcinomas and oropharyngeal carcinomas related to HPV or not.
• Grantee: Paulo Henrique Braz da Silva
• Support Opportunities: Regular Research Grants