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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Resistance of gastrointestinal nematodes to five different active principles in sheep infected naturally in Sao Paulo State, Brazil

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Author(s):
Nagata, Walter Bertequini [1] ; da Cruz Panegossi, Mariele Fernanda [1] ; Saraiva Bresciani, Katia Denise [1] ; Gomes, Jancarlo Ferreira [2] ; Kaneto, Carlos Noriuki [1] ; Venturoli Perri, Silvia Helena [1]
Total Authors: 6
Affiliation:
[1] Univ Estadual Paulista UNESP, Fac Med Vet, R Clovis Pestana 793, BR-16050680 Bairro Ipanema, Aracatuba - Brazil
[2] Univ Estadual Campinas, UNICAMP, Dept Sistemas Informacao, Inst Computacao UNICAMP, LIDS, Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Small Ruminant Research; v. 172, p. 48-50, MAR 2019.
Web of Science Citations: 1
Abstract

This study evaluated the efficacy of commercially available anthelmintic drugs by calculating the percent reduction of eggs per gram (EPGR%) and appropriate statistical tests. A total of 350 animals selected from five commercial sheep farms was divided in seven groups with 10 animals each: Group 1 - control, Group 2 Albendazole (5 mg/kg); Group 3 - Levamisole hydrochloride (5 mg/kg); Group 4 - Ivermectin (0.2 mg/kg); Group 5 - Moxidectin (0.2 mg/kg); and Group 6 - Closantel (10 mg/kg); Group 7 Ivermectin + Levamisole + Albendazole (200 mcg/kg Ivermectin, 7.5 mg/kg Levamisole and 5 mg/kg Albendazole). EPG percent reduction was determined between day zero and day 10 after treatment had started and compared between groups. It was observed that, practically, almost all the tested drugs had some level of parasitic resistance while Moxidectin was the most effective during treatment. The results show that more sustainable procedures such as pasture rotation system, plant-based products, certain fungi and earthworms need to be adopted to reduce parasitism and anthelmintic resistance in ovine herds. (AU)

FAPESP's process: 11/12648-0 - Statistical methods in evaluation of the efficacy of anthelmintic drugs in sheep naturally infected
Grantee:Walter Bertequini Nagata
Support Opportunities: Scholarships in Brazil - Scientific Initiation