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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biological response of chemically treated surface of the ultrafine-grained Ti-6Al-7Nb alloy for biomedical applications

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de Oliveira, Diego Pedreira [1] ; Toniato, Tatiane Venturott [2] ; Ricci, Ritchelli [2] ; Marciano, Fernanda Roberta [3] ; Prokofiev, Egor [4] ; Valiev, Ruslan Z. [5, 4] ; Lobo, Anderson Oliveira [6] ; Jorge Junior, Alberto Moreira [1, 7, 8]
Total Authors: 8
[1] Univ Fed Sao Carlos, Dept Mat Engn, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Vale do Paraiba, Inst Res & Dev, BR-12244000 Sao Paulo - Brazil
[3] Brasil Univ, Sci & Technol Inst, BR-08230030 Sao Paulo - Brazil
[4] St Petersburg State Univ, St Petersburg 199034 - Russia
[5] Ufa State Aviat Tech Univ, Inst Phys Adv Mat, Ufa 450000 - Russia
[6] UFPI Fed Univ Piaui, LIMAV Interdisciplinary Lab Adv Mat, Dept Mat Engn, BR-64049550 Teresina, Piaui - Brazil
[7] Univ Grenoble Alpes, CNRS, Grenoble INP, LEPMI, F-38000 Grenoble - France
[8] SIMAP Labs, F-38000 Grenoble - France
Total Affiliations: 8
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF NANOMEDICINE; v. 14, p. 1725-1736, 2019.
Web of Science Citations: 0

Background: Nanophase surface properties of titanium alloys must be obtained for a suitable biological performance, particularly to facilitate cell adhesion and bone tissue formation. Obtaining a bulk nanostructured material using severe plastic deformation is an ideal processing route to improve the mechanical performance of titanium alloys. By decreasing the grain size of a metallic material, a superior strength improvement can be obtained, while surface modification of a nanostructured surface can produce an attractive topography able to induce biological responses in osteoblastic cells. Methods: Aiming to achieve such an excellent synergetic performance, a processing route, which included equal channel angular pressing (ECAP), hot and cold extrusion, and heat treatments, was used to produce a nanometric and ultrafine-grained (UFG) microstructure in the Ti-6Al-7Nb alloy (around of 200 nm). Additionally, UFG samples were surface-modified with acid etching (UFG-A) to produce a uniform micron and submicron porosity on the surface. Subsequently, alkaline treatment (UFG-AA) produced a sponge-like nanotopographic substrate able to modulate cellular interactions. Results: After several kinds of biological tests for both treatment conditions (UFG-A and UFG-AA), the main results have shown that there was no cytotoxicity, expressed alkaline phosphatase activity and total protein amounts without statistical differences compared to control. However, the UFG-AA samples presented an attractive effect on the cell membranes, and cell adhesions were preferentially induced as compared with UFG-A. Both conditions demonstrated cell projections, but for UFG-AA, cells were more widely dispersed, and more quantities of filopodia formation could be observed. Conclusion: Herein, the reasons for such behaviors are discussed, and further results are presented in addition to those mentioned above. (AU)

FAPESP's process: 13/06258-0 - Development of surfaces anodically oxidized of titanium alloys and modified femtosecond laser and fatigue resistant
Grantee:Diego Pedreira de Oliveira
Support Opportunities: Scholarships in Brazil - Post-Doctorate