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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effective method for the detection of piroxicam in human plasma using HPLC

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Author(s):
Calvo, Adriana Maria [1] ; de Oliveira Prado, Mariel Tavares [1] ; Dionisio, Thiago Jose [1] ; Marques, Maria Paula [2] ; Brozoski, Daniel Thomas [1] ; Lanchote, Vera Lucia [2] ; Cardoso Faria, Flavio Augusto [1] ; Santos, Carlos Ferreira [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, Bauru, SP - Brazil
[2] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Toxicol & Bromatol Anal, Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Brazilian Oral Research; v. 30, 2016.
Web of Science Citations: 0
Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used by the general population to alleviate inflammation and pain after oral surgeries. Piroxicam is among the most commonly used NSAIDs and excels in controlling pain, swelling, trismus and other common symptoms of inflammation. This study aimed to evaluate different concentrations of piroxicam and its major metabolite, 5'-hydroxypiroxicam, in human plasma samples over time using high performance liquid chromatography (HPLC) after liquid-liquid extraction. Briefly, 10 volunteers participated in this study after approval by the Ethics Committee of Bauru School of Dentistry, Universidade de Sao Paulo - USP, Brazil. Volunteers received a single dose oral of piroxicam (20 mg) and had blood collected at various times following an established protocol. The methodology of liquid-liquid extraction was effective for determining concentrations of piroxicam in plasma using HPLC in 10 out of 10 volunteers while 5'-hydroxypiroxicam was only detected in 2 out of 10 volunteers. (AU)

FAPESP's process: 13/18454-8 - Influence of genotype of cytochrome P450 (CYP2C9) on pharmacokinetics of piroxicam
Grantee:Mariel Tavares de Oliveira Prado Bergamo
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 09/17851-8 - Influence of cytochrome P450 (CYP2C9) genotype on the clinical efficacy and pharmacokinetics of piroxicam after lower third molar surgery
Grantee:Adriana Maria Calvo
Support type: Scholarships in Brazil - Post-Doctorate