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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Blood gas analysis in pigs submitted to different concentrations of nitrous oxide or oxygen, under different ventilatory modalities

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Author(s):
Bum, E. G. F. [1] ; Nunes, N. [1] ; Lopes, P. C. F. [2] ; Silva, P. E. S. [1] ; Ido, C. K. [1] ; Silva, H. R. A. [1] ; Horr, M. [1] ; Carneiro, R. L. [1] ; Bompadre, V, T. F.
Total Authors: 9
Affiliation:
[1] Univ Estadual Paulista, Jaboticabal, SP - Brazil
[2] Fac Jaguarinna, Jaguarinna, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Arquivo Brasileiro de Medicina Veterinária e Zootecnia; v. 71, n. 1, p. 35-43, JAN-FEB 2019.
Web of Science Citations: 0
Abstract

ABSTRACT The effects of different concentrations of oxygen and nitrous oxide on blood gas parameters in pigs maintained under spontaneous or pressure-controlled ventilation, with or without positive end-expiratory pressure (PEEP), were compared. Forty-eight pigs were randomly divided into six groups, submitted to different concentrations of compressed air or N2O, associated with different fractions of inspired oxygen (FiO2). The group subject to 30% of compressed air (GA30) showed the closest proximity to the physiological range of partial pressure (PaO2) expected for the species. For oxygen saturation (SaO2), the values obtained were below the lower physiological limit in the group administered 30% N2O (GN30). Use of PEEP positively interfered in PaCO2 independent of FiO2, however, its effectiveness can be compromised when complemented by N2O-based anesthesia. For SaO2, only GN30 showed values lower than adequate for maintaining tissue oxygenation. The pH, base deficit and bicarbonate in arterial blood were influenced by FiO2 and N2O. In conclusion, the use of compressed air maintains blood gas parameters at their most stable, especially GA30 and PEEP, which seemed to positively influence the experimental groups, with some interference from FiO2 and N2O. (AU)

FAPESP's process: 13/25655-0 - Different concentration of nitrous oxide and of oxygen in propofol-anesthetized pigs maintained in spontaneous breathing or in pressure- controlled ventilation with or without PEEP
Grantee:Newton Nunes
Support Opportunities: Regular Research Grants