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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of two protease inhibitors from Bauhinia bauhinoides with different specificity towards gut enzymes of Nasutitermes corniger and its survival

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Author(s):
Ferreira, R. S. [1] ; Brito, V, M. ; Napoleao, T. H. [2] ; Silva, M. C. C. [3] ; Paiva, P. M. G. [2] ; Oliva, V, M. L.
Total Authors: 6
Affiliation:
[1] V, Univ Fed Sao Paulo, Biochem Dept, BR-04044020 Sao Paulo, SP - Brazil
[2] Univ Fed Pernambuco, Biochem Dept, BR-50670420 Recife, PE - Brazil
[3] Brito, M., V, V, Univ Fed Sao Paulo, Biochem Dept, BR-04044020 Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Chemosphere; v. 222, p. 364-370, MAY 2019.
Web of Science Citations: 1
Abstract

Two recombinant protease inhibitors from Bauhinia bauhinioides, rBbKI (kallikrein inhibitor) and rBbCI (cruzipain inhibitor) were evaluated for insecticidal activity against workers and soldiers of Nasutitermes corniger (order: lsoptera; family: Termitidae) through the inhibitors' effect on the insect's gut enzymes. The inhibitor rBbKI was more effective than rBbCI in inhibiting the termite's gut enzymes. The kallikrein inhibitor showed termiticidal activity in workers with an LC50 of 0.9 mg mL(-1) after 4 days. Conversely, rBbKI did not affect the survival of soldiers and rBbCI did not show termiticidal activity against N. corniger. The two inhibitors showed different specificity towards the termite's gut enzymes, representing interesting tools to characterize N. corniger enzymes. The different effects of rBbKI and rBbCI on the termite's enzymes and survival may be linked to slight structural differences between these inhibitors. (C) 2019 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 17/07972-9 - Development of lead agents for prophylaxis and treatment of cardiovascular diseases
Grantee:Maria Luiza Vilela Oliva
Support Opportunities: Regular Research Grants
FAPESP's process: 17/06630-7 - Fragments derived from the structure of protease inhibitors with selectivity for inhibition of mammalian and microorganism enzymes and its role as an anti-inflammatory, antimicrobial, antithrombotic and anti- tumor agent: mechanism of action
Grantee:Maria Luiza Vilela Oliva
Support Opportunities: Research Projects - Thematic Grants