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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Maternal Protein Restriction Differentially Alters the Expression of AQP1, AQP9 and VEGFr-2 in the Epididymis of Rat Offspring

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Author(s):
Cavariani, Marilia Martins [1] ; Santos, Talita de Mello [1] ; Pereira, Dhrielly Natalia [1] ; de Almeida Chuffa, Luiz Gustavo [1] ; Felipe Pinheiro, Patricia Fernanda [1] ; Scarano, Wellerson Rodrigo [2] ; Domeniconi, Raquel Fantin [1]
Total Authors: 7
Affiliation:
[1] Sao Paulo State Univ UNESP, Inst Biosci, Dept Anat, BR-18618970 Botucatu, SP - Brazil
[2] Sao Paulo State Univ UNESP, Inst Biosci, Dept Morphol, BR-18618970 Botucatu, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 20, n. 3 FEB 1 2019.
Web of Science Citations: 3
Abstract

Background: Maternal protein restriction causes sperm alterations in the offspring, most of which are associated with epididymal functions. Because fluid reabsorption/secretion dynamics in the epididymal environment play important roles in the process of sperm maturation and concentration, we investigated the effects of maternal protein restriction on the expression of aquaporins (AQP1 and AQP9), vascular endothelial growth factor (VEGFa), and its receptor VEGFr-2 in different stages of postnatal epididymal development. Methods: Pregnant rats were divided into groups that received normoprotein (17% protein) and low-protein diets (6% protein) during gestation and lactation. After weaning, male rats only received the standard diet and were euthanized at the predetermined ages of 21, 44 and 120 days. Results: Maternal protein restriction decreased AQP1 and AQP9 expression in the initial segment and caput epididymis compared to the increased expression of these proteins observed in the corpus and cauda at all ages. Although protein restriction reduced the microvasculature density (MVD) on postnatal day (PND) 21 and 44, the MVD was unaltered on PND 120. Conclusions: Maternal protein restriction changed the structure or function of the offspring's epididymis, specifically by affecting fluid dynamics and vasculogenesis in important stages of epididymis development. (AU)

FAPESP's process: 16/04085-9 - Wolffian duct development, differentiation and vascular pattern of epididymis in Wistar rats exposed to protein restriction during pregnancy and lactation
Grantee:Raquel Fantin Domeniconi
Support Opportunities: Regular Research Grants
FAPESP's process: 15/18767-1 - Effects of maternal protein restriction on the vascular pattern and protein expression in male Wistar rat epididymis at different stages of postnatal development
Grantee:Marilia Martins Cavariani
Support Opportunities: Scholarships in Brazil - Doctorate