RuCl3/PPh3 - Catalyzed Direct Conversion of Isoxazol-5-ones to 2,3-Disubstituted Pyridines

Fernandes, Alessandra A. G.; Stivanin, Mateus L.; Jurberg, Igor D.

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

RuCl3/PPh3 - Catalyzed Direct Conversion of Isoxazol-5-ones to 2,3-Disubstituted Pyridines

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Author(s):	Fernandes, Alessandra A. G. ^[1] ; Stivanin, Mateus L. ^[1] ; Jurberg, Igor D. ^[1] Total Authors: 3
Affiliation:	^[1] Univ Estadual Campinas, Inst Chem, Dept Organ Chem, Rua Monteiro Lobato 270, BR-13083970 Campinas, SP - Brazil Total Affiliations: 1
Document type:	Journal article
Source:	CHEMISTRYSELECT; v. 4, n. 12, p. 3360-3365, MAR 29 2019.
Web of Science Citations:	2
Abstract
A novel catalytic system employing RuCl3/ PPh3 is described for the preparation of 2,3-disubstituted pyridines starting from 3,4-disubstituted isoxazol-5-ones and acrolein. Mechanistic studies involving P-31 NMR, HRMS analyses and control experiments have been performed in order to support key events and intermediates proposed for this transformation. (AU)

FAPESP's process:	17/24017-0 - Application of Isoxazolones in Organic Synthesis
Grantee:	Igor Dias Jurberg
Support Opportunities:	Regular Research Grants


FAPESP's process:	17/22164-6 - New transformations involving isoxazol-5-ones
Grantee:	Alessandra Aparecida de Godoy Fernandes
Support Opportunities:	Scholarships in Brazil - Doctorate

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