Early ovarian hormone deprivation increases cardiac contractility in old female rats-Role of physical training

Author(s)

Felix, Ana Carolina S. ^[1] ; Gastaldi, Ada C. ^[1] ; Dutra, Sabrina G. V. ^[1] ; Silva de Freitas, Ana Caroline ^[2] ; Philbois, Stella V. ^[1] ; Facioli, Tabata de Paula ^[1] ; Da Silva, Valdo J. D. ^[3] ; Fares, Thauane H. ^[1] ; Dutra de Souza, Hugo Celso ^[1]

Affiliation

^[1] Univ Sao Paulo, Dept Physiol, Ribeirao Preto Med Sch, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Pathol, Ribeirao Preto Med Sch, Sao Paulo - Brazil

^[3] Univ Fed Triangulo Mineiro, Dept Physiol, Uberaba, MG - Brazil

• Document type: Journal article
• Source: AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL; v. 218, p. 1-9, MAY 2019.
• Web of Science Citations: 0

Abstract

Objectives: We investigated the effects of early ovarian hormones deprivation on morphology and cardiac function and the effects of aerobic training on these parameters, in old rats. Methods: Female Wistar rats (N = 48) were divided into two groups, at 10 weeks of life: early ovarian hormones deprivation by ovariectomy (OVX; N = 24) and sham (SHAM; N = 24). Between weeks 62 and 82, 12 animals of each group underwent aerobic training (OVX-T and SHAM-T, N = 12). At the end of week 82, all were evaluated by echocardiography, cardiac function (Langendorff technique) and cardiac beta-adrenergic receptor expression quantification. Results: Echocardiography showed slight changes in morphology between OVX and SHAM groups. OVX group (Delta = 101 +/- 4.7 mmHg) showed higher values for maximal left intraventricular pressure in response to dobutamine, when compared to SHAM group (Delta = 55 +/- 11.8 mmHg). Both OVX-T (Delta = 70 +/- 4.0 mmHg) and SHAM-T (Delta = 22 +/- 6.6 mmHg) groups showed a reduction in this response. While, beta-adrenergic receptor expression was not different between the untrained groups, SHAM-T (0.23 +/- 0.02 AU) and OVX-T (0.29 +/- 0.01 AU), showed decreased expression of these receptors. Conclusion: Early ovarian hormones deprivation associated with aging, promotes discrete changes in cardiac morphology and increasing cardiac contractility. Aerobic training decreases beta-adrenergic receptors expression, influencing the cardiac contractility. (AU)

• FAPESP's process: 14/01937-9 - Longitudinal study of hemodynamic, morphological and functional cardiac adaptations in rats submitted to early and physiological ovarian failure: effect of blockade of angiotensin converting enzyme and aerobic exercise
• Grantee: Hugo Celso Dutra de Souza
• Support Opportunities: Regular Research Grants