| Full text | |
| Author(s): |
Sandrim, Valeria
[1]
;
Coeli-Lacchini, Fernanda Borchers
[2]
;
Tanus-Santos, Jose Eduardo
[3]
;
Lacchini, Riccardo
[4]
;
Cavalli, Ricardo Carvalho
[5, 6]
Total Authors: 5
|
| Affiliation: | [1] Univ Estadual Paulista UNESP, Inst Biosci Botucatu, Dept Pharmacol, Dist Rubiao Jr S-N, BR-18618000 Botucatu, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Coll Nursing, Dept Internal Med, Ribeirao Preto - Brazil
[3] Univ Sao Paulo, Ribeirao Preto Coll Nursing, Dept Pharmacol, Ribeirao Preto - Brazil
[4] Univ Sao Paulo, Ribeirao Preto Coll Nursing, Dept Psychiat Nursing & Human Sci, Ribeirao Preto - Brazil
[5] Univ Sao Paulo, Ribeirao Preto Coll Nursing, Fac Med Ribeirao Preto, Dept Gynecol, Ribeirao Preto - Brazil
[6] Univ Sao Paulo, Ribeirao Preto Coll Nursing, Fac Med Ribeirao Preto, Dept Obstet, Ribeirao Preto - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | HYPERTENSION IN PREGNANCY; v. 38, n. 2, p. 73-77, APR 3 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Objectives: We aimed to assess the plasma HO-1 level and its interrelationship with the plasma sFLT-1 level in preeclamptic and healthy pregnant women with different variants of microsatellite polymorphism (GTn) located in the promoter region of the HMOX-1 gene. Methods: HO-1 and sFLT-1 were measured by ELISA. HMOX1 genotyping was performed using fragment analysis. Results: We found similar and higher levels of plasma HO-1 and sFLT-1, respectively, in preeclampsia. Similar genotypes and alleles frequencies were found in both groups and the absence of modulation of HO-1 levels by genotypes were observed. Conclusion: The plasma HO-1 levels are not increased in preeclampsia women and neither related to sFLT-1 levels and GT(n) polymorphism. (AU) | |
| FAPESP's process: | 15/20461-8 - Role of NRF2 and HO-1 in preeclampsia: polymorphisms, circulating factors and in vitro assays |
| Grantee: | Valeria Cristina Sandrim |
| Support Opportunities: | Regular Research Grants |