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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Aromatic compounds produced by endophytic fungi isolated from red alga Asparagopsis taxiformis-Falkenbergia stage

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Author(s):
Medina, Rebeca P. [1] ; Araujo, Angela R. [1] ; Andersen, Raymond J. [2, 3] ; Soares, Marcos A. [4] ; Silva, Fabio de A. [4] ; Silva, Dulce H. S. [1]
Total Authors: 6
Affiliation:
[1] Univ Estadual Paulista, UNESP, Nucleo Bioensaios Biossintese & Ecofisiol Prod Na, Dept Quim Organ, Inst Quim, Araraquara - Brazil
[2] Univ British Columbia, Dept Earth Ocean & Atmospher Sci, Vancouver, BC - Canada
[3] Univ British Columbia, Dept Chem, Vancouver, BC - Canada
[4] Univ Fed Mato Grosso, Inst Biociencias, Cuiaba - Brazil
Total Affiliations: 4
Document type: Journal article
Source: NATURAL PRODUCT RESEARCH; v. 33, n. 3, p. 443-446, FEB 1 2019.
Web of Science Citations: 1
Abstract

Endophytic fungi were isolated from red alga Asparagopsis taxiformis - Falkenbergia stage, collected from the Brazilian coast, and were identified as Annulohypoxylon stygium (AT-03) and A. yungensis (AT-06) based on their macro/micromorphological and molecular features. Bioassay-guided fractionation of the EtOAc extract from laboratory cultures of both strains yielded known compounds pyrogallol from A. stygium, (3R)-scytalone and (3R,4R)-4-hydroxy-scytalone from A. yungensis. Pyrogallol was active against methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli strains. An inactive fraction from A. stygium afforded two additional compounds, (3R,4R)-3,4,5-trihydroxy-1-tetralone and tyrosol. Optically active compounds had their stereochemistry determined by circular dichroism (CD) spectroscopy. {[}GRAPHICS] . (AU)

FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
Grantee:Glaucius Oliva
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC