Aromatic compounds produced by endophytic fungi isolated from red alga Asparagopsis taxiformis-Falkenbergia stage

Author(s)

Medina, Rebeca P. ^[1] ; Araujo, Angela R. ^[1] ; Andersen, Raymond J. ^{[2, 3]} ; Soares, Marcos A. ^[4] ; Silva, Fabio de A. ^[4] ; Silva, Dulce H. S. ^[1]

Affiliation

^[1] Univ Estadual Paulista, UNESP, Nucleo Bioensaios Biossintese & Ecofisiol Prod Na, Dept Quim Organ, Inst Quim, Araraquara - Brazil

^[2] Univ British Columbia, Dept Earth Ocean & Atmospher Sci, Vancouver, BC - Canada

^[3] Univ British Columbia, Dept Chem, Vancouver, BC - Canada

^[4] Univ Fed Mato Grosso, Inst Biociencias, Cuiaba - Brazil

• Document type: Journal article
• Source: NATURAL PRODUCT RESEARCH; v. 33, n. 3, p. 443-446, FEB 1 2019.
• Web of Science Citations: 2

Abstract

Endophytic fungi were isolated from red alga Asparagopsis taxiformis - Falkenbergia stage, collected from the Brazilian coast, and were identified as Annulohypoxylon stygium (AT-03) and A. yungensis (AT-06) based on their macro/micromorphological and molecular features. Bioassay-guided fractionation of the EtOAc extract from laboratory cultures of both strains yielded known compounds pyrogallol from A. stygium, (3R)-scytalone and (3R,4R)-4-hydroxy-scytalone from A. yungensis. Pyrogallol was active against methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli strains. An inactive fraction from A. stygium afforded two additional compounds, (3R,4R)-3,4,5-trihydroxy-1-tetralone and tyrosol. Optically active compounds had their stereochemistry determined by circular dichroism (CD) spectroscopy. {[}GRAPHICS] . (AU)

• FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
• Grantee: Glaucius Oliva
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC