| Full text | |
| Author(s): |
Luiz, Livia Cocato
[1]
;
Lima Marson, Fernando Augusto
[1, 2, 3]
;
Bresciani Almeida, Celize Cruz
[1]
;
Dalbo Contrera Toro, Adyleia Aparecida
[1]
;
Nucci, Anamarli
[4]
;
Ribeiro, Jose Dirceu
[1, 2]
Total Authors: 6
|
| Affiliation: | [1] Univ Estadual Campinas, Sch Med Sci, Dept Pediat, POB 6111, BR-13081970 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Sch Med Sci, Ctr Pediat Invest, Lab Pulm Physiol, POB 6111, BR-13081970 Campinas, SP - Brazil
[3] Univ Estadual Campinas, Sch Med Sci, Dept Med Genet & Genom Med, POB 6111, BR-13081970 Campinas, SP - Brazil
[4] Univ Estadual Campinas, Sch Med Sci, Dept Neurol, POB 6111, BR-13081970 Campinas, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Respiratory Physiology & Neurobiology; v. 262, p. 1-11, APR 2019. |
| Web of Science Citations: | 1 |
| Abstract | |
Introduction: Duchenne muscular dystrophy(DMD) shows motor and respiratory impairment. Methods: 19 DMD patients (DMDG) (nine ambulatory and 10 non-ambulatory) were evaluated through motor function measure (MFM), 6-minute walk test (6MWT), respiratory muscle strength, cough peak flow, spirometry and volumetric capnography (VCap) tools. Control group that performed spirometry and VCap (CG1-n = 17) were different from those that performed the 6MWT (CG2-n = 8). Results: The follow tools were assessed (p < 0.05): (i) MFM: Ambulatory patients showed higher values than non-ambulatory patients; (ii) 6MWT: DMDG walked a shorter distance and showed higher respiratory rate at rest and heart rate (HR) at rest than CG2; (iii) Spirometry: DMDG and non-ambulatory patients had minor values achieved in spirometry when compared with CG1 and ambulatory patients, respectively; (iv) VCap: DMDG when compared with CG1 showed: (< 11 years-old) lower values in VCap parameters; (> 11 years-old): higher HR and lower slope 2. There was correlation between spirometry, mainly for zFEV(1)/FVC, and MFM. Conclusion DMDG showed motor (MFM/6MWT) and respiratory (spirometry/VCap) deterioration when compared with CG. Non-ambulatory condition was associated with worse MFM and spirometry. (AU) | |
| FAPESP's process: | 11/12939-4 - Association between polymorphisms in modifier genes in children and adolescent with allergic and non-allergic: mild, moderate and severe asthma |
| Grantee: | Fernando Augusto de Lima Marson |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 15/12183-8 - Identification of prevalent mutations and clinical and functional characterization of children and adults with primary ciliary dyskinesia |
| Grantee: | Jose Dirceu Ribeiro |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 11/18845-1 - Association between polymorphisms in modifier genes in children and adolescent with allergic and non-allergic mild, moderate and severe asthma |
| Grantee: | Jose Dirceu Ribeiro |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/12858-5 - Identification of prevalent mutations and clinical and functional characterization of children and adults with primary ciliary dyskinesia |
| Grantee: | Fernando Augusto de Lima Marson |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |