Functional capacity, renal function and vitamin D in community-dwelling oldest old

Author(s)

Quirino Araujo, Lara Miguel ^[1] ; do Prado Moreira, Patricia Ferreira ^[1] ; Almada Filho, Clineu de Mello ^[1] ; de Araujo, Luciano Vieira ^[2] ; Passos, Michelle Tiveron ^[3] ; Kirsztajn, Gianna Mastroianni ^[3] ; Neto, Miguel Cendoroglo ^{[3, 4]} ; Cintra Sesso, Ricardo Castro ^[3] ; Cendoroglo, Maysa Seabra ^[1]

Affiliation

^[1] Univ Fed Sao Paulo, Sch Med, Div Geriatr & Gerontol, Unifesp, Rua Prof Francisco de Castro 105, BR-04020050 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Sch Arts Sci & Humanities, Informat Syst, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Sch Med, Div Nephrol, Unifesp, Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo, Hosp Israelita Albert Einstein, Sao Paulo - Brazil

• Document type: Journal article
• Source: INTERNATIONAL UROLOGY AND NEPHROLOGY; v. 51, n. 4, p. 713-721, APR 2019.
• Web of Science Citations: 0

Abstract

Purpose The aim of this study was to evaluate the association between the decline in estimated glomerular filtration rate (eGFR) and serum 25(OH)D with the physical and mental functional capacity of elderly individuals aged 80 years or older. Methods We evaluated the functional capacity in its multidomain aspects: Geriatric Depression Scale (GDS), Instrumental Activities of Daily Living (IADL), Mental State Mini-Exam (MMSE), Verbal Fluency Test (VF), handgrip strength and time to sit and rise from a chair five times, combined creatinine and cystatin C-based eGFR and 25(OH)D levels in 205 independent asymptomatic and community-dwelling elderly subjects in a cross-sectional study. Results Every 1year of life, there was reduction of about 10% chance of adequate performance in functional capacity. Each 1 ml/min/m(2) in eGFR was associated with 2% better chance of adequate performance in the IADL. We found no association between eGFR and cognition. Serum 25(OH)D between 15.00 and 22.29 ng/ml increased the chance of better performance in VF, IADL, handgrip strength and sit and rise from the chair compared to the lower level of serum vitamin D. Conclusions Decreased renal function associated with age compromises the ability to perform activities for independent life in the community, but we did not observe influence in specific domains of cognition and physical performance. Low serum level of 25(OH)D appears to be a marker of greater risk of functional decline than eGFR measurement in independent oldest old dwelling in the community. (AU)

• FAPESP's process: 11/12753-8 - Renal function markers, vitamin D and functional capacity in elderly
• Grantee: Maysa Seabra Cendoroglo
• Support Opportunities: Regular Research Grants