A general A³: coupling reaction based on functionalized alkynes

Edison P. Wendler; Alcindo A. Dos Santos

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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A general A³: coupling reaction based on functionalized alkynes

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Author(s):	Edison P. Wendler ^[1] ; Alcindo A. Dos Santos ^[2] Total Authors: 2
Affiliation:	^[1] Universidade de São Paulo. Instituto de Química - Brasil ^[2] Universidade de São Paulo. Instituto de Química - Brasil Total Affiliations: 2
Document type:	Journal article
Source:	Química Nova; v. 36, n. 8, p. 1155-1159, 2013-00-00.
Abstract
A range of hydroxypropargylpiperidones were efficiently obtained by a one-pot three-component coupling reaction of aldehydes, alkynols, and a primary amine equivalent (4-piperidone hydrochloride hydrate) in ethyl acetate using copper(I) chloride as a catalyst. The developed protocol proved to be equally efficient using a range of aliphatic aldehydes, including paraformaldehyde, and using protected and unprotected alkynols. (AU)

FAPESP's process:	11/11613-8 - A3-coupling reactions on the synthesis of bioactive nitrogen containing compounds
Grantee:	Alcindo Aparecido dos Santos
Support Opportunities:	Regular Research Grants

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