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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of local tetracycline on the microbiota of alveolar osteitis in rats

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Author(s):
Joseane Maria Dias Bosco [1] ; Sérgio Ricardo de Oliveira [2] ; Álvaro Francisco Bosco [3] ; Christiane Marie Schweitzer ; Elerson Gaetti Jardim Júnior [5]
Total Authors: 5
Affiliation:
[1] São Paulo State University. Dental School of Araçatuba. Department of Surgery and Integrated Clinic - Brasil
[2] São Paulo State University. Dental School of Araçatuba. Department of Surgery and Integrated Clinic - Brasil
[3] São Paulo State University. Dental School of Araçatuba. Department of Surgery and Integrated Clinic - Brasil
[5] São Paulo State University. Dental School of Araçatuba. Department of Pathology and Clinical Propedeutics - Brasil
Total Affiliations: 5
Document type: Journal article
Source: Brazilian Dental Journal; v. 19, n. 2, p. 119-123, 2008-00-00.
Abstract

The aim of the present study was to evaluate the effects of local tetracycline on the occurrence of alveolar osteitis in rats, and on the microbiota associated to this infection. Forty Wistar rats were randomly assigned to 4 groups (n=10): I - the rats had the maxillary right incisor extracted and the alveolar wound did not receive any treatment; II - adrenaline and Ringer-PRAS were introduced into the alveolar wound; III - the alveolar wound was irrigated with sterile saline; and IV - the alveolar wound was irrigated with an aqueous solution of tetracycline. Microbial samples from the alveolar wounds were collected 2 days after surgery and inoculated on blood agar (with and without 8 µg/mL of tetracycline) and other selective media, and were incubated in either aerobiosis or anaerobiosis at 37ºC, for 2 to 14 days. It was verified that tetracycline reduced the occurrence of alveolar osteitis in the rats and caused significant changes in the microbiota of the surgical sites, decreasing the number of anaerobes and increasing the participation of tetracycline-resistant and multi-resistant microorganisms. (AU)