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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Brain derived neurotrophic factor mediated learning, fear acquisition and extinction as targets for developing novel treatments for anxiety

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Author(s):
Karina Soares de Oliveira [1] ; Ana Gabriela Hounie ; Carolina Cappi [3] ; Juliana Belo Diniz [4]
Total Authors: 4
Affiliation:
[1] University of São Paulo Medical School. Hospital das Clínicas - Brasil
[3] University of São Paulo Medical School. Hospital das Clínicas - Brasil
[4] University of São Paulo Medical School. Hospital das Clínicas - Brasil
Total Affiliations: 4
Document type: Journal article
Source: Jornal Brasileiro de Psiquiatria; v. 65, n. 3, p. 251-261, 2016-09-00.
Abstract

ABSTRACT Anxiety and obsessive-compulsive related disorders are highly prevalent and disabling disorders for which there are still treatment gaps to be explored. Fear is a core symptom of these disorders and its learning is highly dependent on the activity of the neurotrophin brain-derived neurotrophic factor (BDNF). Should BDNF-mediated fear learning be considered a target for the development of novel treatments for anxiety and obsessive-compulsive related disorders? We review the evidence that suggests that BDNF expression is necessary for the acquisition of conditioned fear, as well as for the recall of its extinction. We describe the findings related to fear learning and genetic/epigenetic manipulation of Bdnf expression in animals and BDNF allelic variants in humans. Later, we discuss how manipulation of BDNF levels represents a promising potential treatment target that may increase the benefits of therapies that extinguish previously conditioned fear. (AU)

FAPESP's process: 11/00968-0 - Fear conditioning, extinction and recall in obsessive-compulsive disorder patients pre- and post-treatment with serotonin reuptake inhibitors.
Grantee:Juliana Belo Diniz
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 12/09648-0 - Modifications in plasma levels of BDNF and BDNF gene polymorphisms in patients with OCD submitted to fear conditioning paradigm
Grantee:Karina Soares de Oliveira
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 11/21357-9 - Research on neural circuits and biological markers involved in obsessive-compulsive disorder using behavioral paradigms of fear and anxiety
Grantee:Eurípedes Constantino Miguel Filho
Support Opportunities: Research Projects - Thematic Grants