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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of the interaction between genetic factors and maltreatment on child and adolescent psychiatric disorders

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Carvalho, Carolina Muniz [1, 2, 3] ; Pan, Pedro M. [1, 2] ; Ota, Vanessa K. [2, 3] ; Spindola, Leticia M. [1, 2, 3] ; Xavier, Gabriela [2, 3] ; Santoro, Marcos L. [1, 2, 3] ; Mazzotti, Diego R. [4] ; Pellegrino, Renata [5] ; Hakonarson, Hakon [5] ; Rohde, Luis Augusto [6] ; Miguel, Euripedes Constantino [7] ; Gadelha, Ary [1, 2] ; Bressan, Rodrigo A. [1, 2] ; Belangero, Sintia I. [1, 2, 3]
Total Authors: 14
Affiliation:
[1] Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Interdisciplinary Lab Clin Neurosci LINC, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo UNIFESP, Dept Morphol & Genet, Genet Div, Sao Paulo - Brazil
[4] Univ Penn, Ctr Sleep & Circadian Neurobiol, Philadelphia, PA 19104 - USA
[5] Childrens Hosp Philadelphia, Lab Ctr Appl Genom, Philadelphia, PA 19104 - USA
[6] Univ Fed Rio Grande do Sul, Dept Psychiat, Porto Alegre, RS - Brazil
[7] Univ Sao Paulo, Fac Med, Dept Psychiat, Sao Paulo - Brazil
Total Affiliations: 7
Document type: Journal article
Source: PSYCHIATRY RESEARCH; v. 273, p. 575-577, MAR 2019.
Web of Science Citations: 0
Abstract

We evaluated the effects of the interaction between child maltreatment (CM) and single nucleotide polymorphisms (SNPs) on development of mental disorders (MD) and psychopathology. We genotyped 720 individuals from a Brazilian community school-based prospective study, focusing on SNPs in 21 genes known to be associated with mental disorders. CM was assessed via a multi-informant-measure, which was previously validated. To test G x CM, we used linear or logistic models depending on variable evaluated (MD or dimensional psychopathology). After Bonferroni multiple comparison correction, we did not find any statistically significant association of G x CM with either MD or psychopathology. (AU)

FAPESP's process: 08/57896-8 - National Institute for Developmental Psychiatry
Grantee:Eurípedes Constantino Miguel Filho
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/50917-0 - INCT 2014: developmental psychiatry for children and adolescents
Grantee:Eurípedes Constantino Miguel Filho
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/07280-1 - Search for genetic markers of risk, progression and response to treatment
Grantee:Síntia Iole Nogueira Belangero
Support type: Regular Research Grants