Effects of the interaction between genetic factors and maltreatment on child and adolescent psychiatric disorders

Author(s):Show less -

Carvalho, Carolina Muniz ^{[1, 2, 3]} ; Pan, Pedro M. ^{[1, 2]} ; Ota, Vanessa K. ^{[2, 3]} ; Spindola, Leticia M. ^{[1, 2, 3]} ; Xavier, Gabriela ^{[2, 3]} ; Santoro, Marcos L. ^{[1, 2, 3]} ; Mazzotti, Diego R. ^[4] ; Pellegrino, Renata ^[5] ; Hakonarson, Hakon ^[5] ; Rohde, Luis Augusto ^[6] ; Miguel, Euripedes Constantino ^[7] ; Gadelha, Ary ^{[1, 2]} ; Bressan, Rodrigo A. ^{[1, 2]} ; Belangero, Sintia I. ^{[1, 2, 3]}

Affiliation

^[1] Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Interdisciplinary Lab Clin Neurosci LINC, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo UNIFESP, Dept Morphol & Genet, Genet Div, Sao Paulo - Brazil

^[4] Univ Penn, Ctr Sleep & Circadian Neurobiol, Philadelphia, PA 19104 - USA

^[5] Childrens Hosp Philadelphia, Lab Ctr Appl Genom, Philadelphia, PA 19104 - USA

^[6] Univ Fed Rio Grande do Sul, Dept Psychiat, Porto Alegre, RS - Brazil

^[7] Univ Sao Paulo, Fac Med, Dept Psychiat, Sao Paulo - Brazil

• Document type: Journal article
• Source: PSYCHIATRY RESEARCH; v. 273, p. 575-577, MAR 2019.
• Web of Science Citations: 0

Abstract

We evaluated the effects of the interaction between child maltreatment (CM) and single nucleotide polymorphisms (SNPs) on development of mental disorders (MD) and psychopathology. We genotyped 720 individuals from a Brazilian community school-based prospective study, focusing on SNPs in 21 genes known to be associated with mental disorders. CM was assessed via a multi-informant-measure, which was previously validated. To test G x CM, we used linear or logistic models depending on variable evaluated (MD or dimensional psychopathology). After Bonferroni multiple comparison correction, we did not find any statistically significant association of G x CM with either MD or psychopathology. (AU)

• FAPESP's process: 08/57896-8 - National Institute for Developmental Psychiatry
• Grantee: Eurípedes Constantino Miguel Filho
• Support type: Research Projects - Thematic Grants
• FAPESP's process: 14/50917-0 - INCT 2014: developmental psychiatry for children and adolescents
• Grantee: Eurípedes Constantino Miguel Filho
• Support type: Research Projects - Thematic Grants
• FAPESP's process: 14/07280-1 - Search for genetic markers of risk, progression and response to treatment
• Grantee: Síntia Iole Nogueira Belangero
• Support type: Regular Research Grants