| Full text | |
| Author(s): |
de Araujo, Christiane B.
[1]
;
Heimann, Andrea S.
[2]
;
Remer, Ricardo A.
[3]
;
Russo, Lilian C.
[4]
;
Colquhoun, Alison
[5]
;
Forti, Fabio L.
[4]
;
Ferro, Emer S.
[6]
Total Authors: 7
|
| Affiliation: | [1] Butantan Inst, Special Lab Cell Cycle, Ctr Toxins Immune Response & Cell Signaling CeTIC, BR-05503900 Sao Paulo, SP - Brazil
[2] Proteimax Biotecnol LTDA, BR-05581001 Sao Paulo, SP - Brazil
[3] Remer Consultores Ltda, BR-01411001 Sao Paulo, SP - Brazil
[4] Univ Sao Paulo 1111, Inst Chem, Dept Biochem, BR-05508000 Sao Paulo - Brazil
[5] Univ Sao Paulo, Dept Cell & Dev Biol, BR-05508000 Sao Paulo - Brazil
[6] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 6
|
| Document type: | Review article |
| Source: | BIOMOLECULES; v. 9, n. 4 APR 2019. |
| Web of Science Citations: | 1 |
| Abstract | |
Intracellular peptides are produced by proteasomes following degradation of nuclear, cytosolic, and mitochondrial proteins, and can be further processed by additional peptidases generating a larger pool of peptides within cells. Thousands of intracellular peptides have been sequenced in plants, yeast, zebrafish, rodents, and in human cells and tissues. Relative levels of intracellular peptides undergo changes in human diseases and also when cells are stimulated, corroborating their biological function. However, only a few intracellular peptides have been pharmacologically characterized and their biological significance and mechanism of action remains elusive. Here, some historical and general aspects on intracellular peptides' biology and pharmacology are presented. Hemopressin and Pep19 are examples of intracellular peptides pharmacologically characterized as inverse agonists to cannabinoid type 1 G-protein coupled receptors (CB1R), and hemopressin fragment NFKF is shown herein to attenuate the symptoms of pilocarpine-induced epileptic seizures. Intracellular peptides EL28 (derived from proteasome 26S protease regulatory subunit 4; Rpt2), PepH (derived from Histone H2B type 1-H), and Pep5 (derived from G1/S-specific cyclin D2) are examples of peptides that function intracellularly. Intracellular peptides are suggested as biological functional molecules, and are also promising prototypes for new drug development. (AU) | |
| FAPESP's process: | 16/04000-3 - Pharmacology of oligopeptidases and intracellular peptides |
| Grantee: | Emer Suavinho Ferro |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 04/04933-2 - Molecular cell biology of oligopeptidases |
| Grantee: | Emer Suavinho Ferro |
| Support Opportunities: | Research Projects - Thematic Grants |