Prognostic importance of mitochondrial. markers in mucosal and cutaneous head and neck melanomas

Author(s):Show less -

Soares, Ciro Dantas ^[1] ; de Lima Morais, Thayna Melo ^[1] ; Carlos, Roman ^[2] ; de Almeida, Oslei Paes ^[1] ; Mariano, Fernanda Viviane ^{[3, 1]} ; Altemani, Albina ^{[3, 1]} ; Freire de Carvalho, Maria Goretti ^[4] ; Correa, Marcelo Brum ^[5] ; Dias dos Reis, Rodrigo Ribas ^[6] ; Amorim, Luciana Schultz ^[7] ; Jorge, Jacks ^[1]

Affiliation

^[1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Area Pathol, BR-13414903 Piracicaba, SP - Brazil

^[2] Hosp Herrera Llerandi, Ctr Clin Cabeza & Cuello, Pathol Div, Guatemala City 01010 - Guatemala

^[3] Univ Estadual Campinas, Dept Pathol, Fac Med Sci, BR-13083887 Campinas, SP - Brazil

^[4] Private Pathol Serv, BR-59020100 Natal, RN - Brazil

^[5] Fornecedores Cana Hosp, Head & Neck Surg Dept, Oncol Ctr CEON, BR-13405233 Piracicaba, SP - Brazil

^[6] Santa Casa Hosp, Oncol Surg Dept, Canc Ctr CECAN, BR-13419155 Piracicaba, SP - Brazil

^[7] Inst Pathol Anat, BR-13419160 Piracicaba, SP - Brazil

• Document type: Journal article
• Source: HUMAN PATHOLOGY; v. 85, p. 279-289, MAR 2019.
• Web of Science Citations: 2

Abstract

Mitochondrial dysfunction is caused by an imbalance in the fission and fusion processes, and it has been implicated in the pathogenesis of several human cancers. However, the role of mitochondria! markers in melanomas still remains poorly understood. In this study, the authors assessed the expression of 3 mitochondrial markers (antimitochondrial, fission protein 1 {[}FIS1], and mitofusin 2 {[}MFN2]) in a series of head and neck mucosal and cutaneous melanomas. Patients with cutaneous (n = 56) and mucosal (oral, n = 30, sinonasal, n = 26) melanomas of the head and neck region were enrolled in this study. Clinical and follow-up data were retrieved from medical records. The expression of 3 mitochondria] markers was assessed by the immunohistochemistry, and then digitally quantified and correlated with clinicopathological data and outcome information. In the multivariate model, high mitochondrial content was identified as an independent prognostic value for disease-free survival (DFS) in cutaneous melanomas and overall survival in oral melanomas. FIS1 expression was significantly associated with lower overall survival rates in patients with oral melanomas and strictly correlated with vascular invasion in mucosal melanomas. MFN2 was associated with high risk of distant metastasis in patients with cutaneous melanomas. In summary, the authors demonstrated that mitochondrial content, along with FIS1 and MFN2 expressions, is correlated with important clinicopathological characteristics in patients with cutaneous and mucosal head and neck melanomas. (C) 2018 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 15/25905-1 - Akt, COX-2, RUNX1 and MMPs expression in metastatic melanomas and Biotechnology prospection of molecules with antineoplastic activity
• Grantee: Ciro Dantas Soares
• Support Opportunities: Scholarships in Brazil - Doctorate