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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Curcumin improves the effect of a reduced insulin dose on glycemic control and oxidative stress in streptozotocin-diabetic rats

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Author(s):
Gutierres, Vania Ortega [1, 2] ; Assis, Renata Pires [1] ; Arcaro, Carlos Alberto [1] ; Oliveira, Juliana Oriel [1] ; Oliveira Lima, Tayra Ferreira [1] ; Remedio Zeni Beretta, Ana Laura [2] ; Costa, Paulo Inacio [1] ; Baviera, Amanda Martins [1] ; Brunetti, Iguatemy Lourenco [1]
Total Authors: 9
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Clin Anal, Araraquara, SP - Brazil
[2] UNIARARAS, Herminio Ometto Univ Ctr, Grad Program Biomed Sci, 7 Ave Dr Maximiliano Baruto, 500, BR-13607339 Araras, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Phytotherapy Research; v. 33, n. 4, p. 976-988, APR 2019.
Web of Science Citations: 5
Abstract

Insulin with natural antioxidants is emerging as a combination treatment for diabetes mellitus that attempts to exert effective glycemic control without adverse effects. The present study aimed to investigate the additive effects on metabolic disturbances, oxidative damage, and antioxidant defenses in streptozotocin-diabetic rats treated with curcumin and a reduced insulin dose. The best results were obtained in the treatment of diabetic rats with 4-U/day insulin; however, the glycemia levels in these rats were lower than those in normal rats, indicating a risk of hypoglycemia. Isolated treatments using curcumin or insulin in a reduced dose (1U/day) decreased glycemia, dyslipidemia, and biomarkers of liver and kidney damage and increased the activity of hepatic antioxidants (superoxide dismutase and glutathione peroxidase), however, only to a lesser extent than 4-U/day insulin, without improvements in catalase activity or plasma lipid peroxidation. Decreases in glycemia, dyslipidemia, and tissue damage markers were more evident in the curcumin+1-U/day insulin treatment than those seen in isolated treatments. The activity of hepatic antioxidants, including catalase, was further increased, and biomarkers of oxidative damage were decreased. Curcumin with a reduced insulin dose appears to be a promising strategy for combating the complications associated with diabetes and oxidative stress. (AU)