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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genetic Polymorphisms in RANK and RANKL are Associated with Persistent Apical Periodontitis

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Author(s):
Ferreira Petean, Igor Bassi [1] ; Kuchler, Erika Calvano [2] ; Vilarinho Soares, Isadora Mello [1] ; Bezerra Segato, Raquel Assed [2] ; Bezerra da Silva, Lea Assed [2] ; Alves Antunes, Livia Azeredo [3, 4] ; Salles, Alessandro Guimaraes [3, 4] ; Antunes, Leonardo Santos [3, 4] ; de Sousa-Neto, Manoel Damiao [1]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Restorat Dent, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Pediat Dent, Sao Paulo, SP - Brazil
[3] Fluminense Fed Univ, Clin Res Unit, Niteroi, RJ - Brazil
[4] Fluminense Fed Univ, Dept Specif Format, Sch Dent Nova Friburgo, Rio De Janeiro - Brazil
Total Affiliations: 4
Document type: Journal article
Source: JOURNAL OF ENDODONTICS; v. 45, n. 5, p. 526-531, MAY 2019.
Web of Science Citations: 2
Abstract

Introduction: The outcome of root canal treatment has been reported as intimately related to the host response. Genetic polymorphisms might be associated with apical periodontitis repair. The aim of this study was to evaluate the association between receptor activator of nuclear factor kappa B (RANK), receptor activator of nuclear factor kappa B ligand (RANKL), and osteoprotegerin (OPG) genetic polymorphisms with persistent apical periodontitis (PAP) in Brazilian subjects. Methods: Subjects with at least 1 year of follow-up after nonsurgical root canal therapy were recalled. Sixty-four subjects with signs/symptoms of PAP and 86 subjects with root canal treated teeth exhibiting healthy periradicular tissues (healed) were included. Genomic DNA was extracted from saliva and used for RANK (rs3826620), RANKL (rs9594738), and OPG (rs2073618) genotyping by real-time exact tests, and odds ratio were implemented using Epi Info 3.5.2 (Centers for Disease Control and Prevention, Atlanta, GA). A logistic regression analysis was also performed using the time of follow-up as the covariate. All tests were performed with an established alpha of 0.05 (P = .05). Results: An association between allele distribution and the polymorphism in RANK was observed. Subjects who carry the T allele had a lower risk of having PAP (P < .05). In RANKL polymorphism, the genotype distribution was statistically significant different between the PAP and healed groups (P = .05). The time of follow-up was associated with PAP (P < .05). In the logistic regression analysis using time as a covariant, RANK (P < .05) and RANKL (P < .05) were associated with PAP. The polymorphism rs2073618 in OPG was not associated with PAP (P > .05). Conclusions: These findings suggest that polymorphisms in RANK and RANKL genes are associated with PAP. (AU)

FAPESP's process: 15/06866-5 - Evaluation of the role of estrogen in dentofacial development
Grantee:Erika Calvano Kuchler
Support Opportunities: Research Grants - Young Investigators Grants