| Full text | |
| Author(s): Show less - |
Pereira, Rodrigo Martins
[1]
;
da Cruz Rodrigues, Kellen Cristina
[1]
;
Anaruma, Chadi Pellegrini
[1]
;
Sant'Ana, Marcella Ramos
[2]
;
Pereira de Campos, Thais Dantis
[1]
;
Gaspar, Rodrigo Stelizer
[1]
;
Canciglieri, Raphael dos Santos
[1]
;
de Melo, Diego Gomes
[1]
;
Mekary, Rania A.
[3, 4]
;
Ramos da Silva, Adelino Sanchez
[5, 6]
;
Cintra, Dennys Esper
[2]
;
Ropelle, Eduardo Rochete
[1]
;
Pauli, Jose Rodrigo
[1]
;
de Moura, Leandro Pereira
[1]
Total Authors: 14
|
| Affiliation: | [1] Univ Estadual Campinas, Sch Appl Sci, Lab Mol Biol Exercise, Limeira - Brazil
[2] Univ Estadual Campinas, Sch Appl Sci, Lab Nutr Genom, Limeira - Brazil
[3] Harvard Med Sch, Brigham & Womens Hosp, Computat Neurosci Outcomes Ctr, Dept Neurosurg, Boston, MA 02115 - USA
[4] MCPHS Univ, Sch Pharm, Dept Social & Adm Sci, Boston, MA - USA
[5] Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, Ribeirao Preto, SP - Brazil
[6] Univ Sao Paulo, Ribeirao Preto Med Sch, Postgrad Program Rehabil & Funct Performance, Ribeirao Preto, SP - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | Journal of Endocrinology; v. 241, n. 1, p. 59-70, APR 2019. |
| Web of Science Citations: | 1 |
| Abstract | |
Non-alcoholic fatty liver disease (NAFLD) has a positive correlation with obesity, insulin Key Words resistance and type 2 diabetes mellitus (T2D). The aerobic training is an important tool in combating NAFLD. However, no studies have demonstrated the molecular effects of short-term strength training on the accumulation of hepatic fat in obese mice. This study aimed to investigate the effects of short-term strength training on the mechanisms of oxidation and lipid synthesis in the liver of obese mice. The short duration protocol was used to avoid changing the amount of adipose tissue. Swiss mice were separated into three groups: lean control (CTL), sedentary obese (OB) and strength training obese (STO). The obese groups were fed a high-fat diet (HFD) and the STO group performed the strength training protocol 1 session/day for 15 days. The short-term strength training reduced hepatic fat accumulation, increasing hepatic insulin sensitivity and controlling hepatic glucose production. The obese animals increased the mRNA of lipogenic genes Fasn and Scd1 and reduced the oxidative genes Cptla and Ppara. On the other hand, the STO group presented the opposite results. Finally, the obese animals presented higher levels of lipogenic proteins (ACC and FAS) and proinflammatory cytokines (TNF-alpha and IL-1 beta), but the short-term strength training was efficient in reducing this condition, regardless of body weight loss. In conclusion, there was a reduction of obesity-related hepatic lipogenesis and inflammation after short-term strength training, independent of weight loss, leading to improvements in hepatic insulin sensitivity and glycemic homeostasis in obese mice. Key points: (1) Short-term strength training (STST) reduced fat accumulation and inflammation in the liver; (2) Hepatic insulin sensitivity and HPG control were increased with STST; (3) The content and activity of ACC and content of FAS were reduced with STST; (4) STST improved hepatic fat accumulation and glycemic homeostasis; (5) STST effects were observed independently of body weight change. (AU) | |
| FAPESP's process: | 15/07199-2 - Role of clusterin/ApoJ on insulin signalling in response to physical exercise in rodents and humans |
| Grantee: | Leandro Pereira de Moura |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 16/12569-6 - Effects of different exercise intensities on clusterin metabolism and its interference on insulin signaling in rodents |
| Grantee: | Rodrigo Martins Pereira |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |